{"id":"W4406204688","doi":"10.1038/s41541-025-01062-8","title":"A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection","year":2025,"lang":"en","type":"article","venue":"npj Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Alberta Children's Hospital; University of Calgary; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Providence Health Care","funders":"Canadian Institutes of Health Research; Chinese Academy of Sciences; Government of Canada","keywords":"Immunogenicity; Virology; Immune system; Vaccination; Biology; Bivalent (engine); Immunology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006995188,0.0003023156,0.0004790522,0.001048448,0.0003175728,0.00008832406,0.0001193037,0.0002399867,0.00002516928],"category_scores_gemma":[0.002945702,0.00026059,0.0001240846,0.001209819,0.00003261012,0.0001387674,0.0001531274,0.0004119417,0.00003581358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003880472,"about_ca_system_score_gemma":0.0005576168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002235076,"about_ca_topic_score_gemma":0.0003347897,"domain_scores_codex":[0.9979886,0.0002190544,0.0005071417,0.0005721262,0.0002844348,0.0004286663],"domain_scores_gemma":[0.998739,0.0002094695,0.0001285315,0.0005176659,0.0003049826,0.0001003423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006598449,0.0003057753,0.2198824,0.0008419028,0.0001871315,0.0000497785,0.0001647806,0.000002967712,0.7441586,0.00007159165,0.003015884,0.02472076],"study_design_scores_gemma":[0.009869322,0.0008513647,0.4767268,0.0004116171,0.0001689218,0.0001122701,0.00009917552,0.001048441,0.2796789,0.0003262652,0.2303592,0.0003477892],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900205,0.002076487,0.0006904553,0.003845132,0.0004200664,0.00154103,0.000008849775,0.000316005,0.001081533],"genre_scores_gemma":[0.978018,0.0003290492,0.00006629418,0.02030403,0.0003023537,0.0002211128,0.00001170004,0.00003815088,0.0007093058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4644797,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03645693661294504,"score_gpt":0.3570997862259819,"score_spread":0.3206428496130369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}