{"id":"W4406213420","doi":"10.1111/febs.17396","title":"Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma","year":2025,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Pharmacists Association; Western University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Hippo signaling pathway; Scaffold protein; Biology; Melanoma; Gene knockdown; Cancer research; Cell biology; Effector; Crosstalk; Signal transduction; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005012897,0.0001442766,0.0001342507,0.00006740564,0.000211847,0.0001017707,0.0002723743,0.0001086319,0.000035621],"category_scores_gemma":[0.00004236176,0.00008520143,0.00008026912,0.0001548779,0.00008679507,0.000004093301,0.00005878531,0.0002826227,0.00001110176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000222102,"about_ca_system_score_gemma":0.0002871993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001690978,"about_ca_topic_score_gemma":0.0001225799,"domain_scores_codex":[0.9990193,0.0001235971,0.0002098167,0.0002046858,0.0001387848,0.0003037637],"domain_scores_gemma":[0.999507,0.00001873061,0.00008516727,0.0002444916,0.00007790015,0.00006667213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003530492,0.0001001006,0.01012431,0.00001309136,0.0001015914,0.0002011919,0.000305474,0.0003570597,0.9750741,0.0002782819,0.002366386,0.01072536],"study_design_scores_gemma":[0.002569084,0.0009063365,0.0123735,0.0002497145,0.00003112888,0.0007448987,0.001031008,0.00007453423,0.7138047,0.0008722381,0.2668939,0.0004490068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924447,0.001681777,0.001201925,0.001090754,0.000171342,0.00009458607,0.000008702053,0.000007154705,0.003299035],"genre_scores_gemma":[0.9951675,0.00006288454,0.0001770235,0.0005736738,0.0002094793,0.00001087086,0.00001110566,0.00001411367,0.003773342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2645275,"threshold_uncertainty_score":0.3474413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007069370053635373,"score_gpt":0.2317392108655896,"score_spread":0.2246698408119543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}