{"id":"W4406213420","doi":"10.1111/febs.17396","title":"Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma","year":2025,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Pharmacists Association; Western University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Hippo signaling pathway; Scaffold protein; Biology; Melanoma; Gene knockdown; Cancer research; Cell biology; Effector; Crosstalk; Signal transduction; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007937468,0.0002147403,0.0001241097,0.0002345286,0.0001367749,0.0001932786,0.00006661302,0.0001440842,0.0005222769],"category_scores_gemma":[0.00004648782,0.00007229411,0.000134708,0.00009064832,0.0001112695,0.0001982027,0.0001932705,0.0002089594,0.00007238537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310185,"about_ca_system_score_gemma":0.0001114518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002843365,"about_ca_topic_score_gemma":0.0006411637,"domain_scores_codex":[0.9999485,0.00001250475,0.000002545218,0.00001133571,0.00001099037,0.00001423203],"domain_scores_gemma":[0.999979,0.000002077608,0.000008973652,0.00000116553,0.000002541972,0.000006333026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001804913,0.00002732383,0.006817037,0.0001252968,0.0000228035,0.0006353377,0.00006501404,0.0001588293,0.984168,0.0003845922,0.0001110759,0.007304367],"study_design_scores_gemma":[0.0000534238,0.001009017,0.2690269,0.00005728515,0.000145063,0.006849241,0.0005735029,0.005263375,0.6906089,0.001376247,0.02501314,0.00002397036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838267,0.01277659,0.001221707,0.0002170281,0.0000225371,0.00001752666,0.00008294025,0.00003729846,0.001797729],"genre_scores_gemma":[0.9951132,0.003131389,0.0006053948,0.00005104418,0.00001173813,0.00001067516,0.00006651476,0.000003703193,0.001006451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005222769,"threshold_uncertainty_score":0.001747191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007069370053635373,"score_gpt":0.2317392108655896,"score_spread":0.2246698408119543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}