{"id":"W4406213964","doi":"10.1167/iovs.66.1.21","title":"Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns","year":2025,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Corneal Surgery and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre for Blood Research, University of British Columbia; National Science and Technology Council","keywords":"Corneal neovascularization; Fibrosis; Medicine; Inflammation; Neovascularization; Vascular endothelial growth factor; Macrophage polarization; M2 Macrophage; Corneal inflammation; Angiogenesis; Cornea; Immunology; Pathology; Cancer research; Macrophage; Ophthalmology; Biology; VEGF receptors","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0007507692,0.0002063993,0.0004037564,0.0003519279,0.0003189571,0.00004029577,0.000128653,0.0001188885,0.00004570984],"category_scores_gemma":[0.000393194,0.0001757964,0.00003775631,0.001526217,0.002863176,0.0002808274,0.0001454844,0.0002339711,0.00001033196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177736,"about_ca_system_score_gemma":0.000370302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005392333,"about_ca_topic_score_gemma":0.00001570874,"domain_scores_codex":[0.9981354,0.0001700101,0.0003532085,0.0006623656,0.0002188075,0.0004601727],"domain_scores_gemma":[0.9992028,0.0001965371,0.0001145541,0.0001676031,0.0001042859,0.0002142311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000643709,0.0002079794,0.4813482,0.00002730052,0.00001909966,0.0003752595,0.0004403689,0.000007031155,0.5158965,0.0008208645,0.000003261255,0.0007897285],"study_design_scores_gemma":[0.000733342,0.0004867514,0.7518115,0.0002530319,0.00002003626,0.0002142331,0.0002055524,0.000849033,0.220237,0.0250489,0.000009481866,0.0001311298],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970858,0.0003507106,0.00001907378,0.0009092213,0.000340527,0.0004047232,0.000005084714,0.00002945441,0.0008553661],"genre_scores_gemma":[0.9980687,0.00002026511,0.001206108,0.0002929613,0.00001750412,0.00002998305,0.00001557334,0.000008048672,0.0003408381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2956595,"threshold_uncertainty_score":0.9998505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778647322267832,"score_gpt":0.3423945456656909,"score_spread":0.3146080724430126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}