{"id":"W4406219554","doi":"10.1111/jvh.14058","title":"Resistance‐Associated Substitution Testing Trends and Impact on <scp>HCV</scp> Treatment Outcomes in Canada: A <scp>CanHepC</scp>‐<scp>CANUHC</scp> Analysis","year":2025,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Hepatitis C virus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McMaster University; University Health Network; Dalhousie University; William Osler Health System; University of Victoria; University of Calgary; Ottawa Hospital","funders":"AbbVie; Public Health Agency; Public Health Agency of Canada; Gilead Sciences","keywords":"Substitution (logic); Food science; Computer science; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001846674,0.0005118299,0.0007655949,0.00209879,0.002698644,0.002020164,0.001846764,0.0007291975,0.003853747],"category_scores_gemma":[0.006272544,0.0005364195,0.001609904,0.007978324,0.001071478,0.0006083104,0.001702987,0.001428227,0.0003597189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.06140497,"about_ca_system_score_gemma":0.08797878,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9973654,"about_ca_topic_score_gemma":0.9977198,"domain_scores_codex":[0.9967856,0.0002414063,0.0002045536,0.0004019613,0.001116801,0.001249624],"domain_scores_gemma":[0.9894961,0.0005348501,0.001679806,0.0002984536,0.005942388,0.002048379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002367909,0.00003668792,0.9907801,0.0000851763,0.0001764192,0.00006769598,0.0004321469,0.0003066462,0.0001027605,0.0002510866,0.002682059,0.004842409],"study_design_scores_gemma":[0.00002506498,0.00005155626,0.9960075,0.00008110311,0.0001432401,0.00007005121,0.001072433,0.0007655696,0.00007148825,0.0000455278,0.001644029,0.00002244669],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674231,0.001971342,0.0002867287,0.001542707,0.00003994328,0.0001292145,0.02317799,0.00003748722,0.005391523],"genre_scores_gemma":[0.990764,0.000792597,0.0003058509,0.0004345735,0.00001427416,0.00003782023,0.006387927,0.00002785592,0.00123514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06140497,"threshold_uncertainty_score":0.4455263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02511811791186023,"score_gpt":0.3205339203038715,"score_spread":0.2954158023920112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}