{"id":"W4406222527","doi":"10.1002/alz.094584","title":"Driving Tau Pathogenicity Seeding ‐ How Fibril Structure and Post‐Translational Modifications Alter Seeding Capacity","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Seeding; Fibril; Biophysics; Chemistry; Biology; Agronomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002892358,0.0002661904,0.0001706486,0.0001189259,0.0001346543,0.0004902841,0.000205125,0.0002984316,0.001033816],"category_scores_gemma":[0.00042657,0.0001640462,0.0002053469,0.0001001471,0.0001903051,0.0002558529,0.0001753871,0.0005046625,0.000253981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435724,"about_ca_system_score_gemma":0.0001526827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005535589,"about_ca_topic_score_gemma":0.0007484616,"domain_scores_codex":[0.9998592,0.00002103756,0.00001633106,0.00003427183,0.00003789308,0.0000312791],"domain_scores_gemma":[0.9996829,0.0000834458,0.000107636,0.00003601113,0.00004293591,0.0000471085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004913426,0.00001961338,0.0002439625,0.00001717925,0.000004777155,0.00001790204,0.00001069781,0.0001055711,0.9988409,0.00005365195,0.00002075549,0.0006158305],"study_design_scores_gemma":[0.000007572602,0.0001713416,0.003067552,0.000005219868,0.00001337208,0.00007098665,0.00001759033,0.001651335,0.9942089,0.00006315074,0.0007158754,0.000007088987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962587,0.0003827015,0.002407343,0.0000463259,0.00001961914,0.00002650215,0.0001971819,0.00006095579,0.0006007325],"genre_scores_gemma":[0.9973221,0.0002790195,0.001704177,0.00003105659,0.000004509888,0.00001990915,0.0001395936,0.0000249161,0.0004746835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033816,"threshold_uncertainty_score":0.00345844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772668810626229,"score_gpt":0.2490925021454173,"score_spread":0.231365814039155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}