{"id":"W4406224251","doi":"10.1002/alz.088385","title":"Restoring Cognitive functions: Unveiling the Procognitive and Neurotrophic Impact of Chronic Administration of a Selective A5‐GABAA Receptor Positive Allosteric Modulator in Mouse Models of Amyloid Load and Tau Phosphorylation","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Allosteric modulator; Allosteric regulation; Neuroscience; GABAA receptor; Phosphorylation; Brain-derived neurotrophic factor; Long-term potentiation; Pharmacology; Psychology; Amyloid β; Amyloid (mycology); Neurotrophic factors; Receptor; Medicine; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961566,0.001004588,0.0007217898,0.0007135457,0.0003138432,0.0004611337,0.0006174819,0.0007744107,0.001170231],"category_scores_gemma":[0.00009186678,0.000253881,0.0005842391,0.0002628857,0.0006511947,0.0005185824,0.0002173978,0.001933182,0.0003916115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004591649,"about_ca_system_score_gemma":0.000461347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001602415,"about_ca_topic_score_gemma":0.003165797,"domain_scores_codex":[0.9997905,0.00002216173,0.00002378758,0.0000441944,0.00003642092,0.00008292103],"domain_scores_gemma":[0.9998326,0.000009512171,0.00004466034,0.00002282145,0.00001756657,0.0000728212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001194968,0.0007195814,0.0001734523,0.00008161604,0.00002018987,0.00008153513,0.00003579571,0.00007956089,0.9947001,0.0001180493,0.0001424355,0.002652772],"study_design_scores_gemma":[0.0004561458,0.01109344,0.004098936,0.00002835534,0.0001446171,0.0002842911,0.0001114441,0.00119035,0.9799594,0.0001499721,0.002462694,0.00002032312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936488,0.001674551,0.002172854,0.0003028581,0.00009888841,0.0001021077,0.0007172134,0.0002740913,0.001008454],"genre_scores_gemma":[0.9884228,0.002056171,0.004186427,0.000225957,0.00004151186,0.0004029404,0.0006516737,0.00005194582,0.003960541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602415,"threshold_uncertainty_score":0.003914773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04976536545508822,"score_gpt":0.3361031000702432,"score_spread":0.286337734615155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}