{"id":"W4406237831","doi":"10.1016/j.nbd.2025.106802","title":"The brain interactome of a permissive prion replication substrate","year":2025,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Creutzfeldt-Jakob Disease Foundation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Interactome; Permissive; Replication (statistics); Substrate (aquarium); Biology; Neuroscience; Cell biology; Virology; Genetics; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005994684,0.0002058654,0.0001187911,0.0003052156,0.0001836772,0.0002969891,0.0001343237,0.0002263221,0.001233767],"category_scores_gemma":[0.0001086766,0.0001015833,0.0001393028,0.0001144489,0.0001460417,0.0001289277,0.0001782808,0.0002558786,0.0003143729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640343,"about_ca_system_score_gemma":0.0000808627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006809206,"about_ca_topic_score_gemma":0.001325823,"domain_scores_codex":[0.9999418,0.00000657364,0.000002967287,0.00002044897,0.0000156636,0.00001250094],"domain_scores_gemma":[0.9999139,0.00001589125,0.00002779299,0.000008422588,0.000009498568,0.00002448154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006616325,0.000005469082,0.0008442643,0.00001188689,0.000008727325,0.0001533907,0.00002016041,0.00001771135,0.9984068,0.00006222098,0.00002674448,0.0003763991],"study_design_scores_gemma":[0.00001383746,0.0003390113,0.1752362,0.00002605344,0.00008352205,0.004730804,0.0003571541,0.002748108,0.8127881,0.0004200788,0.003238982,0.00001814471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984005,0.0002394216,0.0005122318,0.00002389985,0.000002834492,0.000002386749,0.000189341,0.00001022821,0.0006191513],"genre_scores_gemma":[0.9966491,0.0002380108,0.0009860907,0.00002926543,0.000003555815,0.000007374168,0.0008196436,0.0000141277,0.001252763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233767,"threshold_uncertainty_score":0.004127324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006761153773685575,"score_gpt":0.2828028659268322,"score_spread":0.2760417121531466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}