{"id":"W4406243468","doi":"10.3390/antibiotics14010065","title":"Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights","year":2025,"lang":"en","type":"review","venue":"Antibiotics","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health","funders":"","keywords":"Medicine; Rheumatoid arthritis; Doxycycline; Intensive care medicine; Clinical trial; Anakinra; Minocycline; Arthritis; Disease; Immunology; Antibiotics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009137639,0.0004630591,0.0009490023,0.0009208807,0.00023706,0.001198603,0.0004137322,0.0009863705,0.003987243],"category_scores_gemma":[0.00154935,0.0001759788,0.0008514544,0.0005998022,0.0004194581,0.001025862,0.0004672327,0.001170338,0.0007034078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000513763,"about_ca_system_score_gemma":0.001404724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00096477,"about_ca_topic_score_gemma":0.002288856,"domain_scores_codex":[0.9993826,0.0001870106,0.00008955212,0.00009152728,0.000194188,0.00005500198],"domain_scores_gemma":[0.9991379,0.0004813649,0.00013543,0.00001867065,0.0001904214,0.00003612493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005122722,0.0001459623,0.0008227497,0.06970493,0.000332913,0.0005966189,0.0004155339,0.0006443057,0.01204543,0.01099493,0.02252115,0.8812632],"study_design_scores_gemma":[0.00009552149,0.0009485767,0.002018521,0.0124377,0.0008280856,0.001935307,0.000270909,0.0004097937,0.003420993,0.004461913,0.9731303,0.00004248932],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001554511,0.9945217,0.0004230001,0.001214146,0.0003066317,0.00001426889,0.0000721537,0.00001244771,0.00188117],"genre_scores_gemma":[0.01949175,0.9759226,0.0009941629,0.00118548,0.0006207616,0.00003308211,0.00009447722,0.000007167149,0.001650625],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003987243,"threshold_uncertainty_score":0.01333869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056173959450772,"score_gpt":0.28808649045178,"score_spread":0.2775247508572722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}