{"id":"W4406248307","doi":"10.54254/2753-8818/2024.19897","title":"Klotho in Alzheimer's Disease: Evaluating Therapeutic Potential and Addressing Experimental Challenges","year":2025,"lang":"en","type":"article","venue":"Theoretical and Natural Science","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Klotho; Neuroinflammation; Neurodegeneration; Disease; Neuroscience; Oxidative stress; Cognitive decline; Amyloid (mycology); Medicine; Cognition; Dementia; Bioinformatics; Psychology; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01137005,0.0006424056,0.002023445,0.001119545,0.0003974582,0.002315214,0.001316401,0.001179442,0.001577083],"category_scores_gemma":[0.007911018,0.000262494,0.0008508271,0.0009303848,0.00210139,0.002363584,0.001169092,0.002436401,0.0003551253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001158903,"about_ca_system_score_gemma":0.002681446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009247145,"about_ca_topic_score_gemma":0.001648298,"domain_scores_codex":[0.9977255,0.001089087,0.0003005517,0.0002811302,0.000499054,0.0001045643],"domain_scores_gemma":[0.9953068,0.002889938,0.0004603015,0.0002811503,0.0009124866,0.0001493094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002291272,0.0004442184,0.002691572,0.04064578,0.0006473092,0.00045106,0.0004871054,0.00123134,0.05011265,0.02958346,0.005782961,0.8656312],"study_design_scores_gemma":[0.001171964,0.01621067,0.0215852,0.02904353,0.004875319,0.003058763,0.002343945,0.003574934,0.09175657,0.09364638,0.7323846,0.0003481498],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01236909,0.9692882,0.007879197,0.005159823,0.0009319645,0.0002073618,0.0001898505,0.00005222961,0.003922258],"genre_scores_gemma":[0.07325298,0.9084891,0.01292932,0.002384166,0.001109206,0.0006089649,0.0003176878,0.00003403966,0.0008744213],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01137005,"threshold_uncertainty_score":0.06013125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03558494432737212,"score_gpt":0.386365955068689,"score_spread":0.3507810107413169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}