{"id":"W4406252582","doi":"10.1111/dom.16176","title":"Gastrointestinal tolerability and weight reduction associated with tirzepatide in adults with obesity or overweight with and without type 2 diabetes in the <scp>SURMOUNT</scp> ‐1 to ‐4 trials","year":2025,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Eli Lilly and Company","keywords":"Medicine; Nausea; Placebo; Tolerability; Weight loss; Overweight; Adverse effect; Vomiting; Internal medicine; Type 2 diabetes; Antiemetic; Weight management; Diabetes mellitus; Clinical endpoint; Clinical trial; Obesity; Gastroenterology; Endocrinology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003493974,0.0005720461,0.001576638,0.0003440152,0.000215325,0.0007826687,0.0003466163,0.0005517598,0.002084201],"category_scores_gemma":[0.004094969,0.0002708089,0.003990273,0.0004580218,0.0003118383,0.0005217713,0.0003108072,0.001084033,0.0001444954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349565,"about_ca_system_score_gemma":0.0005517792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006773169,"about_ca_topic_score_gemma":0.002774787,"domain_scores_codex":[0.9982347,0.001101336,0.0002510703,0.0001549393,0.0001637691,0.00009410712],"domain_scores_gemma":[0.9977355,0.0009201601,0.0009386887,0.00008874143,0.0001577457,0.000159166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7716537,0.00133762,0.02786523,0.02601916,0.0441619,0.0002287848,0.0002717384,0.001099719,0.0104906,0.0003290777,0.002401638,0.1141407],"study_design_scores_gemma":[0.6176347,0.1371682,0.1664823,0.003170882,0.0591423,0.001172254,0.0003045156,0.001294122,0.003788641,0.0007293821,0.009012554,0.0001001047],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9216867,0.07142795,0.0005083902,0.0007126841,0.0001991741,0.001172032,0.001217439,0.00005099676,0.003024708],"genre_scores_gemma":[0.982496,0.0142713,0.000677177,0.0004603669,0.0001325126,0.000770546,0.0007272651,0.000009829077,0.0004550249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003493974,"threshold_uncertainty_score":0.01847816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263508857942536,"score_gpt":0.2473143678169976,"score_spread":0.2346792792375722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}