{"id":"W4406269742","doi":"10.1089/derm.2024.0418","title":"Long-Term Safety and Efficacy with Roflumilast Cream 0.15% in Patients Aged ≥6 Years with Atopic Dermatitis: A Phase 3 Open-Label Extension Trial","year":2025,"lang":"en","type":"article","venue":"Dermatitis","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia; Queen's University; Probity Medical Research; University of Toronto","funders":"","keywords":"Medicine; Open label; Atopic dermatitis; Roflumilast; Dermatology; Term (time); Safety profile; Clinical trial; Adverse effect; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008663691,0.0002339508,0.0005823437,0.0002182922,0.0001373553,0.00007940223,0.0001569325,0.0001245091,0.00008734471],"category_scores_gemma":[0.0001066156,0.0001901652,0.00002874286,0.0003339735,0.0001952677,0.0002987291,0.0001151307,0.0002326163,0.00002001774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005267605,"about_ca_system_score_gemma":0.0001717502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004424365,"about_ca_topic_score_gemma":0.0002040657,"domain_scores_codex":[0.9985177,0.0001422514,0.0004350487,0.0003699777,0.0002341639,0.0003008626],"domain_scores_gemma":[0.9991111,0.000133758,0.0001204937,0.0003855292,0.00008584947,0.0001632906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0152378,0.006247956,0.9286705,0.0004257217,0.0002513654,0.002319052,0.0005529372,0.000002599376,0.000006054884,0.00006104894,0.02490225,0.02132276],"study_design_scores_gemma":[0.2132004,0.0007212246,0.7835883,0.001117538,0.000162475,0.0001302782,0.00003008992,0.00003452019,0.00005907846,0.00001608269,0.0007739289,0.0001661111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946774,0.0005854695,0.000193107,0.0009000191,0.0001213476,0.00189089,0.00003766905,0.00005856729,0.001535506],"genre_scores_gemma":[0.9947259,0.0001345281,0.0002606414,0.004172525,0.00002239839,0.0000821909,0.0002596855,0.00002261582,0.0003195103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1979626,"threshold_uncertainty_score":0.7754712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387316337308278,"score_gpt":0.2927316325968286,"score_spread":0.2788584692237457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}