{"id":"W4406270682","doi":"10.1101/2025.01.07.629892","title":"ATR and PKMYT1 Inhibition Resensitizes a Subset of TNBC Patient-Derived Models to Carboplatin, Inducing Mitotic Catastrophe","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Carboplatin; Cancer research; Triple-negative breast cancer; Gene knockdown; DNA damage; Biology; Medicine; Cisplatin; Cancer; Chemotherapy; Apoptosis; Internal medicine; Genetics; Breast cancer; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009323943,0.0003139856,0.0002837481,0.0002155573,0.0001286851,0.0001661614,0.0001501509,0.0002135454,0.001383917],"category_scores_gemma":[0.00005729753,0.0001114139,0.0002242592,0.0001325303,0.0001234824,0.0001044963,0.0001106588,0.0006864838,0.0002115111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528749,"about_ca_system_score_gemma":0.0001981271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006933477,"about_ca_topic_score_gemma":0.001454475,"domain_scores_codex":[0.999916,0.000007870041,0.000009028004,0.00002361772,0.00002329938,0.00002030418],"domain_scores_gemma":[0.9999666,0.000004024784,0.000007866477,0.000005067402,0.00000371239,0.00001268955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000164872,0.00006818012,0.000154016,0.00003489031,0.000006361668,0.0000483695,0.0000119509,0.0001276851,0.9976659,0.00008109464,0.0001358707,0.001500983],"study_design_scores_gemma":[0.00004835498,0.001309045,0.004038278,0.000005310464,0.00002310955,0.0006343002,0.00002238027,0.001558666,0.9888699,0.00004107106,0.003445856,0.000003768215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948254,0.001060626,0.001411519,0.0001235893,0.00003825493,0.00006638135,0.0008962636,0.0001097462,0.00146812],"genre_scores_gemma":[0.9922826,0.0008107571,0.001822588,0.00005870753,0.000007259495,0.00008484722,0.001624163,0.0000153295,0.003293871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383917,"threshold_uncertainty_score":0.004629731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250862710766002,"score_gpt":0.2101327084871796,"score_spread":0.1976240813795196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}