{"id":"W4406270685","doi":"10.1002/ejhf.3579","title":"Sacubitril/Valsartan Versus Valsartan Initiation in Patients Naïve to Renin–angiotensin System Inhibitors: Insights from PARAGLIDE-HF","year":2025,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Sherbrooke","funders":"Novartis Pharmaceuticals Corporation","keywords":"Valsartan; Medicine; Sacubitril; Heart failure; Confidence interval; Internal medicine; Clinical endpoint; Ejection fraction; Cardiology; Sacubitril, Valsartan; Randomization; Angiotensin receptor; Renin–angiotensin system; Natriuretic peptide; Angiotensin II; Angiotensin Receptor Blockers; Randomized controlled trial; Urology; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002911227,0.0004068782,0.001916485,0.0002489896,0.0001370212,0.0005949515,0.0003700132,0.0005134938,0.002303065],"category_scores_gemma":[0.002365928,0.0001723134,0.001465779,0.000196876,0.0003953948,0.0004503248,0.0002420705,0.001124225,0.0001708896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052878,"about_ca_system_score_gemma":0.0005834533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003354635,"about_ca_topic_score_gemma":0.001313145,"domain_scores_codex":[0.9983284,0.001240516,0.00007920416,0.0001220465,0.00009727497,0.0001325925],"domain_scores_gemma":[0.9983733,0.001023617,0.0002783138,0.00007235242,0.00006303425,0.0001894191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7652409,0.007283309,0.02272348,0.002386443,0.007230576,0.0002270683,0.000234428,0.001122863,0.01293567,0.001026166,0.0009564601,0.1786326],"study_design_scores_gemma":[0.3098421,0.4681737,0.1849382,0.000565537,0.01602028,0.0004105519,0.000491277,0.007109444,0.004149897,0.003049277,0.005156043,0.00009384438],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976956,0.01958393,0.0005773053,0.0008084312,0.0001726158,0.0001828532,0.0001768466,0.00001082742,0.001531107],"genre_scores_gemma":[0.9951692,0.002991233,0.0005752655,0.0004773059,0.000344666,0.0000756332,0.0001197711,0.000002718912,0.0002440955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002911227,"threshold_uncertainty_score":0.01539624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214105609729583,"score_gpt":0.2481278499805738,"score_spread":0.235986793883278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}