{"id":"W4406289379","doi":"10.1038/s41467-025-55909-8","title":"Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; McMaster University; BC Mental Health & Substance Use Services; Ontario Brain Institute; Douglas Mental Health University Institute; Alberta Children's Hospital; McGill University; University of Calgary; Michael Smith Health Research BC; BC Children's Hospital; Hotchkiss Brain Institute; University of British Columbia","funders":"National Center for Advancing Translational Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Foundation for the National Institutes of Health","keywords":"Buccal swab; Buccal administration; Cheek; Epigenetics; Biomarker; Medicine; Physiology; Age changes; Biology; Dentistry; Genetics; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00187025,0.0003803587,0.0003911263,0.0005492836,0.0003377567,0.0009893191,0.0003029015,0.0003837834,0.001644116],"category_scores_gemma":[0.003204644,0.000236127,0.0002888299,0.0005565738,0.0004155118,0.0004206494,0.0006849725,0.0003982977,0.000373679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615399,"about_ca_system_score_gemma":0.0003079667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003229602,"about_ca_topic_score_gemma":0.00789675,"domain_scores_codex":[0.9986643,0.0004806464,0.0001133956,0.0003149936,0.0003042071,0.0001224413],"domain_scores_gemma":[0.9984863,0.0005798159,0.0003585503,0.0002340501,0.0002726235,0.00006877767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007014696,0.00004575522,0.8373284,0.0002101424,0.000169694,0.0003973054,0.0009025225,0.0004949291,0.1133071,0.000315967,0.0003476265,0.045779],"study_design_scores_gemma":[0.00000444359,0.0003251264,0.9430999,0.00004268339,0.0001000945,0.0007620546,0.0005477068,0.0005146221,0.05035609,0.0001832359,0.004047099,0.00001684222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828696,0.004107244,0.008715671,0.0002143402,0.00007408658,0.0000515767,0.001914439,0.00004268765,0.002010443],"genre_scores_gemma":[0.9901154,0.001308484,0.005977503,0.0001743739,0.00002587206,0.00006106896,0.0008323691,0.00002741543,0.001477462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003229602,"threshold_uncertainty_score":0.009890914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03791992210034523,"score_gpt":0.3994574912278863,"score_spread":0.3615375691275411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}