{"id":"W4406305519","doi":"10.1128/jvi.01235-24","title":"Sensing of SARS-CoV-2-infected cells by plasmacytoid dendritic cells is modulated via an interplay between CD54/ICAM-1 and CD11a/LFA-1 α <sub>L</sub> integrin","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Université de Montréal","keywords":"Biology; CD11a; Plasmacytoid dendritic cell; Cell biology; Cell culture; Interferon; Interferon type I; Virology; Integrin; Dendritic cell; Immunology; Cell; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007679474,0.0002170946,0.0002405367,0.00008734835,0.0001427954,0.0003805771,0.00009679062,0.0002406736,0.000610716],"category_scores_gemma":[0.00009932563,0.0001206425,0.0002150388,0.00009013055,0.000141203,0.0002047377,0.0002341816,0.0003012346,0.0002605628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754595,"about_ca_system_score_gemma":0.0001521371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003097966,"about_ca_topic_score_gemma":0.0004226825,"domain_scores_codex":[0.9998473,0.00002686395,0.00001115271,0.00003082553,0.00002850086,0.00005525836],"domain_scores_gemma":[0.9999505,0.000006352916,0.00001618309,0.000005846512,0.000009244849,0.00001174854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005058275,0.000007241234,0.000687465,0.00001122066,0.000002187261,0.00004250689,0.00001201592,0.00003570397,0.9985469,0.00004109831,0.00001385026,0.0005492148],"study_design_scores_gemma":[0.00003027514,0.0003231791,0.05068253,0.00001024677,0.00003122319,0.0006918476,0.0002385729,0.003576459,0.9420293,0.0001696625,0.002204446,0.00001224093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980593,0.0003967675,0.0007467006,0.00004777427,0.000008071355,0.000008202951,0.00006221155,0.00001383766,0.0006570464],"genre_scores_gemma":[0.9985043,0.0002601287,0.0006629929,0.00003138564,0.000005622607,0.000009549648,0.00007762495,0.000003545876,0.0004448845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000610716,"threshold_uncertainty_score":0.002043009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046576550454628,"score_gpt":0.3404097354647919,"score_spread":0.3199439699602457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}