{"id":"W4406305778","doi":"10.3390/biom15010115","title":"Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Royal Golden Jubilee (RGJ) Ph.D. Programme; University of Alberta; National Research Council of Thailand; Canadian Institutes of Health Research; Mitacs; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Small interfering RNA; Gene silencing; Apoptosis; Chemistry; Flow cytometry; Leukemia; Cancer research; Myeloid leukemia; Cell; RNA interference; Molecular biology; Cell biology; Biology; Transfection; Immunology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251544,0.0001417251,0.0001783722,0.00009439504,0.00003398969,0.00001041445,0.000336432,0.000115825,0.000007109435],"category_scores_gemma":[0.00002392957,0.0001085657,0.0001352049,0.0001857871,0.0002706454,0.000005136872,0.0001272451,0.00005765632,0.000003746018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000186092,"about_ca_system_score_gemma":0.0002724366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006968363,"about_ca_topic_score_gemma":0.0002125614,"domain_scores_codex":[0.9990918,0.00005652154,0.0003053093,0.0002358217,0.000112919,0.0001976058],"domain_scores_gemma":[0.9994243,0.00001920081,0.00009311047,0.0003608032,0.00007663734,0.00002594661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002052176,0.00006287355,0.001249839,0.00002539308,0.00008553766,0.000001814975,0.0001251951,0.0005050234,0.9890426,0.000307427,0.0002429289,0.008146096],"study_design_scores_gemma":[0.0004015548,0.0001966092,0.001824366,0.00005306934,0.00003370567,0.000001743479,0.0003347342,0.003679874,0.992891,0.0003842681,0.00009113423,0.0001079867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948203,0.002939079,0.0006292165,0.0002152971,0.00006001032,0.0001337056,0.00001573951,0.000004073326,0.001182583],"genre_scores_gemma":[0.9985266,0.0004325677,0.0001194476,0.0005083439,0.0000151617,0.00001752279,0.00001068301,0.00001036647,0.0003593516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008038109,"threshold_uncertainty_score":0.4427179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008283185623834741,"score_gpt":0.2571758943421805,"score_spread":0.2488927087183457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}