{"id":"W4406305778","doi":"10.3390/biom15010115","title":"Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Royal Golden Jubilee (RGJ) Ph.D. Programme; University of Alberta; National Research Council of Thailand; Canadian Institutes of Health Research; Mitacs; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Small interfering RNA; Gene silencing; Apoptosis; Chemistry; Flow cytometry; Leukemia; Cancer research; Myeloid leukemia; Cell; RNA interference; Molecular biology; Cell biology; Biology; Transfection; Immunology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003091036,0.0004161421,0.0002160924,0.0002448413,0.0001300249,0.0002707467,0.0003622622,0.0004691572,0.0006646737],"category_scores_gemma":[0.0001764636,0.0001749557,0.0002622868,0.0001706393,0.0002044942,0.0002499836,0.0001814927,0.0005803459,0.0005492072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003731669,"about_ca_system_score_gemma":0.0002030448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007177062,"about_ca_topic_score_gemma":0.0007647423,"domain_scores_codex":[0.9998456,0.00003028565,0.00001530138,0.0000403716,0.00004810165,0.00002027214],"domain_scores_gemma":[0.9999211,0.000014698,0.00002729448,0.000008875116,0.00001741467,0.00001066357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004073794,0.00001967116,0.00001688498,0.0000345874,0.000002646596,0.00003497178,0.000007042554,0.0001542436,0.9986002,0.0001690879,0.00003486242,0.0008851144],"study_design_scores_gemma":[0.000007209548,0.0001343307,0.0001329542,0.000002921512,0.000006277865,0.00004472343,0.000002941518,0.001118356,0.9970868,0.00002267623,0.001438529,0.000002235065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.918251,0.003302626,0.07226255,0.0003153485,0.00009517388,0.0004274672,0.0007294489,0.0005275435,0.004088967],"genre_scores_gemma":[0.9479008,0.002105059,0.04316547,0.00007222542,0.00001128815,0.0003191421,0.0006256481,0.00009773935,0.005702614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007177062,"threshold_uncertainty_score":0.002707541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008283185623834741,"score_gpt":0.2571758943421805,"score_spread":0.2488927087183457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}