{"id":"W4406312686","doi":"10.1212/nxg.0000000000200232","title":"Neonatal Encephalopathy","year":2025,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Toronto; SickKids Foundation; Hospital for Sick Children; Alberta Health Services; McMaster Children's Hospital; University of Alberta","funders":"National Heart, Lung, and Blood Institute; Uniwersytet Warszawski; International Society on Thrombosis and Haemostasis","keywords":"In silico; Gene; Encephalopathy; Pathogenicity; Biology; Copy-number variation; Genetic variants; Genetics; Medicine; Computational biology; Bioinformatics; Genome; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004161915,0.0001137006,0.00008845898,0.0000467972,0.00006963155,0.00001174771,0.0002252575,0.0001496747,0.00001720536],"category_scores_gemma":[0.00003359851,0.000116125,0.00006683667,0.0000703066,0.0001009327,5.926785e-7,0.0001724788,0.0000782326,0.00001861053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001999651,"about_ca_system_score_gemma":0.00009556424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002102827,"about_ca_topic_score_gemma":0.00001317914,"domain_scores_codex":[0.9992573,0.00004045717,0.0001282769,0.000316378,0.00004787384,0.0002097225],"domain_scores_gemma":[0.9995236,0.000008804519,0.00002856907,0.000336954,0.00004814739,0.0000539097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007568336,0.0003160982,0.2072081,0.00006060254,0.0002308118,0.000258747,0.0000977338,0.001738158,0.663669,0.002994236,0.04355389,0.07911583],"study_design_scores_gemma":[0.0008243249,0.0005847985,0.08126538,0.000002983227,0.00004561523,0.00008494085,0.00001966922,0.0002154561,0.06881963,0.001242618,0.8466244,0.0002701915],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909699,0.00374566,0.001015374,0.0005074455,0.000573709,0.00009907698,0.0000193718,0.00001341757,0.003056046],"genre_scores_gemma":[0.9935059,0.000557184,0.0002414077,0.004765731,0.0001382762,0.00001229461,0.00005569997,0.00001225771,0.0007112738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8030705,"threshold_uncertainty_score":0.4735438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003484937414979425,"score_gpt":0.2267427667924162,"score_spread":0.2232578293774367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}