{"id":"W4406313049","doi":"10.1021/acs.chemrev.4c00761","title":"Synthetic Lipid Biology","year":2025,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Bioorthogonal chemistry; Chemistry; Synthetic biology; Chemical biology; Biological membrane; Protocell; Membrane biophysics; Biomolecule; Membrane; Nanotechnology; Computational biology; Biochemistry; Biology; Combinatorial chemistry; Click chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007351888,0.001330707,0.0008552778,0.001877859,0.0006760664,0.002056512,0.001361333,0.001668347,0.008326036],"category_scores_gemma":[0.0008564378,0.0005058508,0.0006287709,0.001500751,0.001398642,0.003037396,0.0019368,0.003312574,0.008636226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001939922,"about_ca_system_score_gemma":0.00144796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205833,"about_ca_topic_score_gemma":0.001384816,"domain_scores_codex":[0.9995248,0.00007144752,0.0000422489,0.00009682847,0.0002139659,0.00005064224],"domain_scores_gemma":[0.9997821,0.00008815845,0.00002544907,0.00002809074,0.00005135053,0.00002479647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005703597,0.0001099929,0.0001537733,0.01031407,0.00008015564,0.0002971832,0.0001846336,0.001191829,0.01055669,0.1980287,0.09307425,0.6859517],"study_design_scores_gemma":[0.000005418162,0.00001643062,0.00003661893,0.0004093109,0.000006976126,0.0001930515,0.00001247068,0.0000656668,0.001622707,0.006066483,0.9915572,0.00000748786],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000503029,0.9505966,0.005751207,0.001475175,0.001814193,0.00005878221,0.0001500534,0.0001299574,0.03952092],"genre_scores_gemma":[0.006661166,0.9691669,0.005018646,0.001382457,0.0005903927,0.0001322056,0.000323643,0.00004297925,0.01668158],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008326036,"threshold_uncertainty_score":0.02785331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02432621834925687,"score_gpt":0.3274577116451981,"score_spread":0.3031314932959412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}