{"id":"W4406314026","doi":"10.1093/ecco-jcc/jjaf005","title":"Risankizumab efficacy and safety based on prior inadequate response or intolerance to advanced therapy: post hoc analysis of the INSPIRE and COMMAND phase 3 studies","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Calgary","funders":"AbbVie","keywords":"Medicine; Placebo; Internal medicine; Post-hoc analysis; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02439454,0.00116847,0.003328451,0.0005528469,0.0003440639,0.001289064,0.001060416,0.0008424448,0.003248095],"category_scores_gemma":[0.01221614,0.0004379344,0.008809685,0.0006531547,0.0008281553,0.0008379279,0.000786774,0.001752601,0.0002714026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005979161,"about_ca_system_score_gemma":0.001229621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003999111,"about_ca_topic_score_gemma":0.0009414021,"domain_scores_codex":[0.9862494,0.01027575,0.0007617173,0.0009645544,0.001023147,0.0007254188],"domain_scores_gemma":[0.9759385,0.01562989,0.003642132,0.002691781,0.001225857,0.0008718384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8852573,0.001785056,0.04629308,0.0008512379,0.03675902,0.0002082225,0.000184406,0.001917242,0.006628091,0.0001825129,0.001758461,0.0181753],"study_design_scores_gemma":[0.2041661,0.2746026,0.4223942,0.0002213942,0.07067998,0.0007499772,0.0003270322,0.009810656,0.009719511,0.0007756987,0.0063588,0.0001940687],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928237,0.002359939,0.001132986,0.0001416272,0.00007753132,0.0008145987,0.001388524,0.00005682177,0.001204308],"genre_scores_gemma":[0.9956202,0.0002670629,0.0008275833,0.0001949586,0.00007756855,0.0007630681,0.001683646,0.00003312231,0.0005327811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02439454,"threshold_uncertainty_score":0.1290122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046419563016766,"score_gpt":0.3095270820903964,"score_spread":0.2990628864602288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}