{"id":"W4406322533","doi":"10.1101/2025.01.09.632110","title":"Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"","keywords":"Limiting; Arabidopsis; ATP synthase; Component (thermodynamics); Identification (biology); Inositol; Biology; Chemistry; Cell biology; Computational biology; Biochemistry; Botany; Gene; Engineering; Mutant; Physics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001226495,0.0006253016,0.001006899,0.0001418573,0.0001543995,0.0002336257,0.0009394234,0.000648418,0.00008555128],"category_scores_gemma":[0.001004508,0.0003898327,0.0003095057,0.0007721094,0.00008416118,0.0001709513,0.0003590522,0.000755954,0.0000533279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002764447,"about_ca_system_score_gemma":0.0004381831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007273393,"about_ca_topic_score_gemma":0.00006680149,"domain_scores_codex":[0.9957781,0.0005027413,0.001366982,0.001216402,0.000483123,0.0006526027],"domain_scores_gemma":[0.9970254,0.0007259451,0.001033412,0.0004796216,0.0003724224,0.0003631719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002073307,0.0002582375,0.02116883,0.0001762218,0.0001052785,0.00007747396,0.000009967125,0.0001983177,0.9773573,0.0001884155,0.0002089661,0.00004362514],"study_design_scores_gemma":[0.001079359,0.0000850618,0.2264219,0.0009954696,0.0002056977,5.591215e-8,0.00001531466,0.002059626,0.7672011,0.000008559535,0.001097362,0.0008305314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923196,0.001595656,0.000106221,0.000810226,0.0007856478,0.00155627,0.002609758,0.0001980962,0.00001854562],"genre_scores_gemma":[0.9985636,0.0001968021,0.0002056093,0.0003892739,0.0003973721,0.0002096302,0.000006630327,0.000008953349,0.00002214096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2101563,"threshold_uncertainty_score":0.9998553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009905904048624464,"score_gpt":0.2011982205538795,"score_spread":0.191292316505255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}