{"id":"W4406332962","doi":"10.55563/clinexprheumatol/hjt118","title":"Phase 3, 56-week, randomised, double-blind, placebo-controlled study utilising patient-reported and radiographic outcomes evaluating the efficacy and safety of a lorecivivint injection in patients with moderate to severe knee osteoarthritis: OA-11 Study","year":2024,"lang":"en","type":"article","venue":"Clinical and Experimental Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Radiography; Physical therapy; Surgery; Internal medicine; Nuclear medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003659626,0.002059354,0.004773208,0.0005913002,0.0009079445,0.001290634,0.001617986,0.002956133,0.006941839],"category_scores_gemma":[0.002477717,0.001125305,0.00195666,0.0007050121,0.002127312,0.001265546,0.000489018,0.00368957,0.001447696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006623754,"about_ca_system_score_gemma":0.002200539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006802396,"about_ca_topic_score_gemma":0.001952791,"domain_scores_codex":[0.998752,0.0006286083,0.00009317508,0.0002117397,0.0001257693,0.000188658],"domain_scores_gemma":[0.9978341,0.0005334084,0.0005820428,0.0002326792,0.0002267565,0.0005910271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9691117,0.01634005,0.0004955308,0.0005797321,0.0003728836,0.00003352247,0.00007541821,0.0002366203,0.005632332,0.00005240824,0.0004194565,0.006650292],"study_design_scores_gemma":[0.9159221,0.08168504,0.001391885,0.00001667203,0.0001165555,0.00001904898,0.00001250184,0.0001669505,0.0003831989,0.0000389988,0.0002348352,0.0000122272],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741808,0.002606629,0.001651694,0.000421863,0.0004588005,0.01731213,0.00157477,0.000244792,0.00154848],"genre_scores_gemma":[0.9561013,0.002228993,0.004842444,0.001635793,0.0007682243,0.02868714,0.001659065,0.00007199377,0.004004988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006941839,"threshold_uncertainty_score":0.02322274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04338449163644262,"score_gpt":0.3698159950550342,"score_spread":0.3264315034185915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}