{"id":"W4406332962","doi":"10.55563/clinexprheumatol/hjt118","title":"Phase 3, 56-week, randomised, double-blind, placebo-controlled study utilising patient-reported and radiographic outcomes evaluating the efficacy and safety of a lorecivivint injection in patients with moderate to severe knee osteoarthritis: OA-11 Study","year":2024,"lang":"en","type":"article","venue":"Clinical and Experimental Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Radiography; Physical therapy; Surgery; Internal medicine; Nuclear medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009561789,0.0003234615,0.001390413,0.0002399998,0.0001732683,0.00006164771,0.00004356348,0.0001167891,0.00001528743],"category_scores_gemma":[0.000193202,0.0001977911,0.0001241701,0.0002338385,0.0002232818,0.000120656,0.000121629,0.0002447228,0.000001019352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002354986,"about_ca_system_score_gemma":0.00005176256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001141498,"about_ca_topic_score_gemma":0.0001735938,"domain_scores_codex":[0.9969425,0.0004751584,0.001330873,0.0006789748,0.0002970017,0.0002755545],"domain_scores_gemma":[0.9984055,0.0008869744,0.0002052576,0.0002400468,0.00007158385,0.0001906063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4944658,0.007855158,0.4474123,0.00002468996,0.000572247,0.0000664571,0.006035013,0.000005051511,0.00004653127,0.00001533651,0.000001631495,0.04349984],"study_design_scores_gemma":[0.8512664,0.1118288,0.02610189,0.0004211341,0.0005652594,0.0001298458,0.009090022,0.0002665133,0.00009300845,0.00001730965,0.000001787071,0.0002179575],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871033,0.001797298,0.000007987362,0.00007027144,0.0003339639,0.01061376,0.00000638226,0.00004509088,0.00002190263],"genre_scores_gemma":[0.9991736,0.00002484761,0.00007662649,0.00004165747,0.00001168832,0.0006109687,0.00001803152,0.00002888057,0.00001369705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4213104,"threshold_uncertainty_score":0.8065688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04338449163644262,"score_gpt":0.3698159950550342,"score_spread":0.3264315034185915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}