{"id":"W4406333430","doi":"10.55563/clinexprheumatol/gskbin","title":"A Phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients","year":2024,"lang":"en","type":"article","venue":"Clinical and Experimental Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Physical therapy; Knee Joint; Double blind; Randomized controlled trial; Surgery; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009975411,0.0002278569,0.001269594,0.000148211,0.00005866447,0.00001972962,0.00007808411,0.0001449934,0.00007716248],"category_scores_gemma":[0.0005151361,0.0001326691,0.0002177563,0.0001740817,0.0002276531,0.000059839,0.00009562582,0.0001554709,0.00000888537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002873792,"about_ca_system_score_gemma":0.00006981441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004284145,"about_ca_topic_score_gemma":0.00002316605,"domain_scores_codex":[0.997135,0.0004746311,0.001515257,0.0003687028,0.0002710436,0.0002353479],"domain_scores_gemma":[0.997978,0.001389683,0.0001818476,0.000223521,0.00008290682,0.0001440109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9760622,0.005601633,0.0001943606,0.0001038579,0.0001822228,0.00001077712,0.005013515,0.00001125261,0.002708866,0.0001739471,0.00004694797,0.009890361],"study_design_scores_gemma":[0.9361491,0.04602478,0.0001612176,0.0007288387,0.0002087314,0.0000678915,0.001151721,0.0007173613,0.01455896,0.00008363619,0.00002434967,0.0001233928],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893494,0.001506956,0.00003893179,0.0002958009,0.0005228044,0.008102309,0.00002014689,0.00001589775,0.0001477029],"genre_scores_gemma":[0.9989889,0.00005671576,0.0002094188,0.00008144028,0.00002484963,0.0005601457,0.00002456122,0.00001776159,0.00003620486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04042314,"threshold_uncertainty_score":0.5410088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04756461628777568,"score_gpt":0.3500323073591807,"score_spread":0.302467691071405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}