{"id":"W4406333430","doi":"10.55563/clinexprheumatol/gskbin","title":"A Phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients","year":2024,"lang":"en","type":"article","venue":"Clinical and Experimental Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Physical therapy; Knee Joint; Double blind; Randomized controlled trial; Surgery; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003098972,0.001848607,0.003145961,0.0004508951,0.000705419,0.001029583,0.001215665,0.002388746,0.00707915],"category_scores_gemma":[0.002189202,0.0008169435,0.001605839,0.0003996314,0.00170919,0.001113898,0.0004081888,0.003110908,0.001229266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007347626,"about_ca_system_score_gemma":0.002242916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000846237,"about_ca_topic_score_gemma":0.003140884,"domain_scores_codex":[0.9991071,0.0004684964,0.00005058608,0.0001693338,0.00007655802,0.0001279184],"domain_scores_gemma":[0.9985227,0.0003994753,0.0003493189,0.0001021829,0.0001284456,0.000497824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9682303,0.01208259,0.000362675,0.0007956954,0.0003598478,0.00004632934,0.00008695877,0.0002343498,0.005226803,0.00007498982,0.0006587105,0.01184065],"study_design_scores_gemma":[0.9366691,0.06186327,0.0007597489,0.00001637164,0.00008726511,0.00002199558,0.000008820896,0.0001270933,0.0002107811,0.00003469835,0.0001933321,0.000007447275],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818658,0.003602841,0.001153907,0.0006082894,0.0004818714,0.00914589,0.001193036,0.0002043295,0.001743981],"genre_scores_gemma":[0.9667299,0.002962079,0.004645955,0.00220355,0.0006339657,0.01706921,0.001616857,0.0000489848,0.00408949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00707915,"threshold_uncertainty_score":0.02368212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04756461628777568,"score_gpt":0.3500323073591807,"score_spread":0.302467691071405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}