{"id":"W4406347659","doi":"10.1016/j.spinee.2024.12.029","title":"Chronic low back pain causal risk factors identified by Mendelian randomization: a cross-sectional cohort analysis","year":2025,"lang":"en","type":"article","venue":"The Spine Journal","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Medicine; Mendelian randomization; Cohort; Cross-sectional study; Randomization; Cohort study; Physical therapy; Internal medicine; Randomized controlled trial; Genetics; Pathology; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09440925,0.001573654,0.002282522,0.002729858,0.001091974,0.001512469,0.00230611,0.001805444,0.004444316],"category_scores_gemma":[0.1416202,0.001131332,0.007284742,0.002058594,0.001233696,0.0009390761,0.001590714,0.001570997,0.000250006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007433578,"about_ca_system_score_gemma":0.00191736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00372979,"about_ca_topic_score_gemma":0.002496161,"domain_scores_codex":[0.9264167,0.06055209,0.003281603,0.006665179,0.002229028,0.0008553273],"domain_scores_gemma":[0.8987741,0.07370586,0.00885864,0.01606635,0.001980364,0.0006145864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03714067,0.00130592,0.7178843,0.004715175,0.08540209,0.003460306,0.0015142,0.02347447,0.004338164,0.03171332,0.003762996,0.08528849],"study_design_scores_gemma":[0.03055426,0.02137193,0.2868824,0.002232055,0.2017296,0.005631119,0.001028043,0.350556,0.004496649,0.07511771,0.01998259,0.0004176162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5486333,0.006643241,0.4303001,0.0007314807,0.0005216351,0.008437086,0.002435208,0.0007005963,0.001597249],"genre_scores_gemma":[0.8848017,0.0007609452,0.1086579,0.0003292118,0.00008001677,0.004179981,0.0007318797,0.00004496392,0.0004133468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09440925,"threshold_uncertainty_score":0.4992898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007333294109073729,"score_gpt":0.2837757624235936,"score_spread":0.2764424683145199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}