{"id":"W4406350282","doi":"10.1371/journal.pone.0317281","title":"Anti-inflammatory effects of moxifloxacin and levofloxacin on cadmium-activated human astrocytes: Inhibition of proinflammatory cytokine release, TLR4/STAT3, and ERK/NF-κB signaling pathway","year":2025,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine, Chulalongkorn University; Chulalongkorn University; University of Alberta","keywords":"Neuroinflammation; Proinflammatory cytokine; Pharmacology; MAPK/ERK pathway; Inflammation; Signal transduction; NF-κB; TLR4; Chemistry; Cancer research; Biology; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206678,0.0004217262,0.0005325538,0.0002218887,0.0001918734,0.0002025234,0.0001460633,0.0002561429,0.0007152079],"category_scores_gemma":[0.00009107313,0.0001217972,0.0003920438,0.0001697788,0.0001743988,0.0001758622,0.0001972318,0.0004758321,0.0001194511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001480814,"about_ca_system_score_gemma":0.0003679096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337724,"about_ca_topic_score_gemma":0.002762408,"domain_scores_codex":[0.99988,0.00002153553,0.00001455188,0.00002002796,0.0000228941,0.00004108436],"domain_scores_gemma":[0.9999592,0.000004824778,0.000009411173,0.000003326648,0.000009591686,0.00001367407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009429905,0.000108238,0.0001557844,0.0001870756,0.00001447571,0.00006364812,0.0000243227,0.00006597008,0.9954359,0.00001986297,0.00004878973,0.002932938],"study_design_scores_gemma":[0.0001535866,0.003019088,0.009073536,0.0000297005,0.00006486387,0.0002642369,0.00009129398,0.0008974939,0.9832507,0.00003996906,0.003102612,0.0000130279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893205,0.008295147,0.0009693162,0.0001716678,0.00005614723,0.00005589239,0.0002464738,0.00004373826,0.0008411781],"genre_scores_gemma":[0.9917367,0.003904439,0.002036416,0.0001321679,0.00002131065,0.00007821689,0.0004694222,0.000008257251,0.001613058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337724,"threshold_uncertainty_score":0.002659857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561144301854369,"score_gpt":0.2269573007905645,"score_spread":0.2013458577720208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}