{"id":"W4406352769","doi":"10.1007/s11523-024-01126-0","title":"Buparlisib and Paclitaxel in Patients with Head and Neck Squamous Cell Carcinoma: Immunogenomic Biomarkers of Efficacy from the BERIL-1 Study","year":2025,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Paclitaxel; Head and neck; Head and neck squamous-cell carcinoma; Basal cell; Internal medicine; Oncology; Carcinoma; Head and neck cancer; Chemotherapy; Radiation therapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570443,0.0001544273,0.0005920678,0.0000906956,0.00007782515,0.000004497389,0.00007034637,0.00008249222,0.00001446657],"category_scores_gemma":[0.00007079614,0.00009910976,0.00002450934,0.0002138558,0.0002170883,0.00002308172,0.0001084985,0.0001663193,0.000001106103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159177,"about_ca_system_score_gemma":0.0001797732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003406701,"about_ca_topic_score_gemma":0.001343907,"domain_scores_codex":[0.9989538,0.0001380908,0.0003075646,0.0002868928,0.00009512223,0.0002185517],"domain_scores_gemma":[0.9991219,0.0004424869,0.00008588569,0.0002374275,0.00006246729,0.00004985118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003512874,0.001181136,0.9863645,0.00003702402,0.0001243156,0.00001821673,0.003746551,5.942315e-7,0.0009951292,0.000003406947,0.0004384978,0.003577773],"study_design_scores_gemma":[0.0214771,0.005228142,0.9697378,0.00003731852,0.0001788015,8.293126e-7,0.002373351,0.000007194043,0.0002203153,0.00001318496,0.0006424159,0.00008359611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911042,0.006243971,9.117491e-7,0.0004993839,0.0001145651,0.001017844,0.00003522217,0.00001163141,0.0009723046],"genre_scores_gemma":[0.9994565,0.00004039798,0.0001389499,0.0002458659,0.00001789775,0.00003136251,0.00001848567,0.00001117563,0.00003935587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01796423,"threshold_uncertainty_score":0.5149935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106481787802106,"score_gpt":0.2746714922898457,"score_spread":0.264023313509635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}