{"id":"W4406352769","doi":"10.1007/s11523-024-01126-0","title":"Buparlisib and Paclitaxel in Patients with Head and Neck Squamous Cell Carcinoma: Immunogenomic Biomarkers of Efficacy from the BERIL-1 Study","year":2025,"lang":"en","type":"article","venue":"Targeted Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Paclitaxel; Head and neck; Head and neck squamous-cell carcinoma; Basal cell; Internal medicine; Oncology; Carcinoma; Head and neck cancer; Chemotherapy; Radiation therapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001297134,0.0003455026,0.0006906859,0.0002289018,0.0001770435,0.0007079786,0.0002427401,0.0003919186,0.001099063],"category_scores_gemma":[0.001479873,0.0001436814,0.0006471934,0.0003761183,0.0002347228,0.0005859095,0.0002843536,0.001032786,0.000168463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006863059,"about_ca_system_score_gemma":0.0005299132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008199774,"about_ca_topic_score_gemma":0.002478983,"domain_scores_codex":[0.9995903,0.0001982924,0.00002247289,0.00004619059,0.00006765829,0.0000749297],"domain_scores_gemma":[0.9992452,0.0002542719,0.0002560415,0.00004763093,0.00007868306,0.0001182572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.242093,0.003981917,0.3862742,0.001703064,0.01095995,0.0002266739,0.0002521941,0.002000191,0.01712815,0.0005265387,0.005673261,0.3291808],"study_design_scores_gemma":[0.02698451,0.07190132,0.8697727,0.0003076215,0.01057986,0.0006393085,0.0004311595,0.002021129,0.005622554,0.0006371325,0.01102558,0.0000772897],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859329,0.01111041,0.00008000714,0.0007140139,0.00005482478,0.00006978613,0.0004109446,0.000009122662,0.001618032],"genre_scores_gemma":[0.9948936,0.002970628,0.0001377049,0.0005968296,0.00008043932,0.00004815185,0.0006739346,0.000003123889,0.0005956991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297134,"threshold_uncertainty_score":0.006859958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106481787802106,"score_gpt":0.2746714922898457,"score_spread":0.264023313509635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}