{"id":"W4406360388","doi":"10.1038/s41467-025-55934-7","title":"Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Sorbonne Université; Centre National de la Recherche Scientifique; Société Française de Dermatologie et de Pathologie Sexuellement Transmissible; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Immune system; Medicine; Disease; Immunology; Inflammation; Phenotype; Endotype; Immune dysregulation; Biology; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003611303,0.0004349063,0.0004437528,0.0004022068,0.0001988969,0.001209502,0.0001537817,0.0002379203,0.0008013448],"category_scores_gemma":[0.0005173694,0.0001308954,0.0003349756,0.0002829123,0.0005312524,0.0004283869,0.0006589527,0.0005223941,0.0001622437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093598,"about_ca_system_score_gemma":0.0003063377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005755411,"about_ca_topic_score_gemma":0.0007215263,"domain_scores_codex":[0.9996247,0.0001231192,0.00002087385,0.0001203745,0.00006717693,0.00004372161],"domain_scores_gemma":[0.9997111,0.00008537665,0.00009562771,0.00004267024,0.00003221877,0.00003303224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004370063,0.000151696,0.08946638,0.0004104586,0.0003679804,0.001478552,0.0006624633,0.02825384,0.7593374,0.01215745,0.0009928775,0.1062839],"study_design_scores_gemma":[0.0000626116,0.001229384,0.473703,0.00009798769,0.0003165746,0.0049631,0.00119809,0.3064335,0.1274723,0.06312145,0.02126802,0.0001340427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8993287,0.001728292,0.09377195,0.0004047513,0.00005614442,0.00005248369,0.0004779767,0.0003085547,0.003871084],"genre_scores_gemma":[0.9822176,0.0004754218,0.01609484,0.00009936647,0.00002674757,0.00002549509,0.0002703983,0.00001785235,0.0007723697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209502,"threshold_uncertainty_score":0.002680779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01759077967691747,"score_gpt":0.2764610875871186,"score_spread":0.2588703079102012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}