{"id":"W4406362160","doi":"10.1038/s41467-025-55967-y","title":"The small GTPase MRAS is a broken switch","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Genome Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"GTPase; Guanine nucleotide exchange factor; GTP'; Biology; Cell biology; Small GTPase; MRAS; Molecular switch; Function (biology); Computational biology; Chemistry; Biochemistry; Signal transduction; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004568217,0.0002567197,0.0004997091,0.0003210568,0.0007319287,0.001584867,0.000552688,0.0006762665,0.001370038],"category_scores_gemma":[0.0005681994,0.0002469259,0.0003166095,0.0002776495,0.001802176,0.002005209,0.0009297153,0.001666557,0.001217819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005496424,"about_ca_system_score_gemma":0.0003689099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092666,"about_ca_topic_score_gemma":0.0002274544,"domain_scores_codex":[0.9995272,0.00006012713,0.00002356189,0.0001471955,0.0001739146,0.00006786248],"domain_scores_gemma":[0.9997177,0.00004655551,0.00005617783,0.00006822802,0.00004117822,0.00007015829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004559147,0.00001983571,0.0009518323,0.0001452237,0.00003250903,0.0005675401,0.0002057971,0.0005289692,0.9015822,0.06253357,0.001802034,0.03117462],"study_design_scores_gemma":[0.00007091018,0.0007613173,0.005442231,0.00008433917,0.00006937498,0.004523804,0.0006905674,0.00399501,0.5455858,0.06665324,0.3719777,0.0001457509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8878292,0.0249606,0.04857465,0.008995946,0.001974778,0.00003183122,0.0004951806,0.002166993,0.02497079],"genre_scores_gemma":[0.9748877,0.004949016,0.009196595,0.001021666,0.0002815652,0.00002122678,0.0002662825,0.0001289421,0.009247085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584867,"threshold_uncertainty_score":0.00458324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038701455234309,"score_gpt":0.2714958955922704,"score_spread":0.2611088810399273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}