{"id":"W4406364289","doi":"10.1016/j.phrs.2025.107602","title":"Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial","year":2025,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint Mary's University; Canadian Institutes of Health Research","funders":"Canadian Institutes of Health Research; Tertiary Education Trust Fund","keywords":"Glycemic; Type 2 diabetes; Phosphofructokinase; Medicine; Randomized controlled trial; Double blind; Diabetes mellitus; Clinical trial; Pharmacology; Internal medicine; Traditional medicine; Endocrinology; Alternative medicine; Glycolysis; Metabolism; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003364617,0.0002924561,0.001407901,0.0004196022,0.0001260823,0.00007268877,0.0003110249,0.0003796831,0.001262715],"category_scores_gemma":[0.004321959,0.0001867026,0.0002076692,0.001266294,0.0004697457,0.00008942466,0.0002002281,0.001529097,0.0002568177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518068,"about_ca_system_score_gemma":0.000410644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001394807,"about_ca_topic_score_gemma":0.000003106269,"domain_scores_codex":[0.9953704,0.001120817,0.0009062515,0.0008321331,0.0008581153,0.000912239],"domain_scores_gemma":[0.9930879,0.005178691,0.00009528024,0.0003796825,0.0006811713,0.0005772461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.925538,0.002149684,0.06195598,0.00002960448,0.0005375645,0.00002529353,0.00003622997,0.00001109294,0.003551878,0.00006968264,0.001809668,0.00428532],"study_design_scores_gemma":[0.9748423,0.005866675,0.01127993,0.0001088461,0.0003569562,8.584946e-8,0.00003187806,0.002138216,0.003524658,0.0004858884,0.001167095,0.0001975482],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875372,0.0004570259,0.00005088807,0.001325471,0.000818535,0.007596164,0.00002993174,0.00008269364,0.002102093],"genre_scores_gemma":[0.9936468,0.00009237077,0.0001876291,0.003698948,0.0003418364,0.001281598,0.00007033368,0.00002328574,0.0006571875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05067605,"threshold_uncertainty_score":0.9996502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08949023832142528,"score_gpt":0.4415021074691933,"score_spread":0.352011869147768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}