{"id":"W4406364993","doi":"10.1016/j.msard.2025.106269","title":"Potential mechanisms of how B-cell depletion works in MOGAD","year":2025,"lang":"en","type":"editorial","venue":"Multiple Sclerosis and Related Disorders","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Massachusetts General Hospital","keywords":"Medicine; Multiple sclerosis; Dermatology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007115693,0.002894882,0.002236842,0.001758148,0.002059495,0.004239852,0.00302869,0.01456785,0.005191045],"category_scores_gemma":[0.008535198,0.0009104225,0.002007911,0.000552451,0.002220348,0.003142545,0.001491782,0.01793792,0.003056544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002369884,"about_ca_system_score_gemma":0.001449232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009224034,"about_ca_topic_score_gemma":0.002547249,"domain_scores_codex":[0.9979394,0.0004443134,0.0002810264,0.0002866205,0.0008248049,0.0002238886],"domain_scores_gemma":[0.9947801,0.002101115,0.0003274824,0.0001788358,0.001467692,0.001144846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001980752,0.00003404669,0.0000649171,0.000418993,0.00005271742,0.0004649043,0.00002487218,0.00004407941,0.0004201915,0.001425578,0.9832236,0.01362801],"study_design_scores_gemma":[0.0003006561,0.0001171671,0.0005682955,0.0003506505,0.0001749967,0.0007352193,0.00005175164,0.0003212997,0.0006267116,0.003273045,0.9934493,0.0000309866],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0001211443,0.01198539,0.0002752489,0.0387305,0.9471596,0.00002465726,0.0000254732,0.00004266129,0.001635393],"genre_scores_gemma":[0.001233525,0.006520957,0.0001975824,0.02817417,0.9559494,0.00003325658,0.00001883108,0.00002007809,0.00785224],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01456785,"threshold_uncertainty_score":0.03763181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006078453973629121,"score_gpt":0.1857050611352269,"score_spread":0.1796266071615978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}