{"id":"W4406373742","doi":"10.1101/2025.01.13.632747","title":"Global molecular landscape of early MASLD progression in obesity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Health and Medical Research Council; Novo Nordisk Fonden; Science for Life Laboratory; Vetenskapsrådet; Robert Bosch Stiftung; Agency for Science, Technology and Research; Knut och Alice Wallenbergs Stiftelse; National Medical Research Council; European Federation of Pharmaceutical Industries and Associations; National Research Foundation; European Commission; Novo Nordisk; Diamond Light Source; McGill University","keywords":"Metabolome; Steatosis; Biology; Transcriptome; Fatty liver; Fibrosis; Gene signature; Cancer research; Liver injury; Gene knockdown; Metabolomics; Pathology; Internal medicine; Endocrinology; Bioinformatics; Gene expression; Medicine; Gene; Disease; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002879496,0.0003013208,0.0002751626,0.0008168758,0.0001822816,0.0007197333,0.0001250848,0.0002441532,0.004369328],"category_scores_gemma":[0.0002751655,0.0001428277,0.0003246989,0.0006903727,0.0001953023,0.0002625405,0.0004101837,0.0005044626,0.0006468836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277897,"about_ca_system_score_gemma":0.00021215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005831418,"about_ca_topic_score_gemma":0.0006344586,"domain_scores_codex":[0.9998578,0.00001972114,0.000004400506,0.00006327722,0.0000266188,0.00002815807],"domain_scores_gemma":[0.9998471,0.00003691683,0.00005713387,0.0000139261,0.00002174401,0.0000232587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001865023,0.0001004828,0.1305447,0.001734344,0.0007939582,0.0008982973,0.0005400164,0.007638797,0.7132131,0.00771981,0.01990813,0.1150434],"study_design_scores_gemma":[0.00007758951,0.000457818,0.8003553,0.00032993,0.0007104193,0.001743304,0.0008297013,0.01735816,0.08944447,0.01663838,0.07191034,0.0001445719],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9215131,0.01338616,0.01480087,0.002145871,0.0001393784,0.00004282463,0.04157179,0.001011078,0.005388814],"genre_scores_gemma":[0.9623085,0.005404461,0.007308429,0.0003821428,0.00009721319,0.00005129399,0.02033593,0.0001364616,0.003975462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004369328,"threshold_uncertainty_score":0.01461685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008960355539643557,"score_gpt":0.2527580205416055,"score_spread":0.243797665001962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}