{"id":"W4406375561","doi":"10.1016/j.cardfail.2024.10.027","title":"Phase Ib Study Of Hs135, A Novel Activin And Gdf Inhibitor, In Patients With Obesity-related Heart Failure With Preserved Ejection Fraction And Pulmonary Hypertension Leveraging Remote Pulmonary Artery Pressure Monitoring Technology","year":2025,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Medicine; Cardiology; Internal medicine; Pulmonary artery; Ejection fraction; Pulmonary hypertension; Heart failure; Heart failure with preserved ejection fraction; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001115686,0.001508994,0.002263363,0.0003106629,0.0003773419,0.001274826,0.0007458317,0.001208357,0.002798251],"category_scores_gemma":[0.0005928521,0.0005391892,0.001963731,0.0002987136,0.001123102,0.00105044,0.000355857,0.003820678,0.0006761743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008400904,"about_ca_system_score_gemma":0.001913404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001605184,"about_ca_topic_score_gemma":0.003158033,"domain_scores_codex":[0.9996942,0.00008711265,0.00001389995,0.00006260366,0.00002576797,0.0001164057],"domain_scores_gemma":[0.999526,0.00005576436,0.00005668245,0.00003904886,0.00003116065,0.000291291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7684029,0.10154,0.004107182,0.0006737493,0.002674384,0.0001810648,0.0002764434,0.002651338,0.04152971,0.0006168889,0.003701138,0.07364523],"study_design_scores_gemma":[0.5647455,0.4234743,0.00516394,0.00002947966,0.0007432062,0.000105849,0.00009020751,0.0008790329,0.002531401,0.0002712045,0.001931936,0.00003388274],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896058,0.002425783,0.001374508,0.0007719687,0.000351109,0.002413189,0.0009294139,0.0001092025,0.002019045],"genre_scores_gemma":[0.9867277,0.002319496,0.00194239,0.001754765,0.0003026025,0.002470414,0.001916941,0.0000287084,0.002536985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002798251,"threshold_uncertainty_score":0.009361088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065145437975024,"score_gpt":0.255375202135707,"score_spread":0.2447237477559568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}