{"id":"W4406378400","doi":"10.14740/wjon1936","title":"Activity-Regulated Cytoskeleton-Associated Protein Gene Expression Is Associated With High Infiltration of Stromal Cells and Immune Cells, but With Less Cancer Cell Proliferation and Better Overall Survival in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers","year":2025,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; National Institutes of Health; American Association for Cancer Research; U.S. Department of Defense","keywords":"Stromal cell; Medicine; Infiltration (HVAC); Immune system; Estrogen receptor; Cancer research; Gene; Cell biology; Receptor; Cancer cell; Estrogen; Immunology; Cancer; Breast cancer; Internal medicine; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176302,0.0001539351,0.0003048097,0.0007992641,0.0002879592,0.0004457108,0.0001906002,0.0001799731,0.001949329],"category_scores_gemma":[0.000530071,0.0001167596,0.000269784,0.001258545,0.0001803113,0.0001479317,0.0003145939,0.000261894,0.0002321357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002631941,"about_ca_system_score_gemma":0.0002429091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002293441,"about_ca_topic_score_gemma":0.004971568,"domain_scores_codex":[0.9998453,0.00001737449,0.0000132882,0.00006652101,0.00003074497,0.00002680499],"domain_scores_gemma":[0.9996281,0.00004973697,0.0001955911,0.00004121114,0.00003933903,0.00004604324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006909153,0.00004629934,0.9453647,0.0001822665,0.0003277797,0.0002359244,0.0001039122,0.0002523102,0.04159635,0.00009980554,0.001588094,0.009511649],"study_design_scores_gemma":[0.00001119413,0.00003080618,0.9968095,0.000007497282,0.0001084094,0.0005166316,0.00005182556,0.0002414826,0.001381464,0.0000763647,0.0007612323,0.000003586178],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945185,0.0006440604,0.000284675,0.00003845936,0.00000566604,0.000007387908,0.003803617,0.00002790663,0.0006696776],"genre_scores_gemma":[0.9937857,0.0003131423,0.0003824044,0.00003195842,0.000006600511,0.00002337745,0.005015889,0.00001230519,0.0004286093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002293441,"threshold_uncertainty_score":0.006521165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008743969670917432,"score_gpt":0.2488439344142707,"score_spread":0.2400999647433533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}