{"id":"W4406380891","doi":"10.1038/s41380-025-02891-8","title":"Altered tRNA expression profile associated with codon-specific proteomic changes in the suicide brain","year":2025,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute on Drug Abuse; National Institutes of Health; American Foundation for Suicide Prevention; National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"Transfer RNA; Proteomics; Prefrontal cortex; Translation (biology); Biology; Amino acid; Methylation; Bioinformatics; Genetics; Gene; Neuroscience; RNA; Messenger RNA; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130177,0.0002408862,0.0002879048,0.0005923835,0.0001897073,0.0002828853,0.00008915733,0.0001975539,0.0006298318],"category_scores_gemma":[0.0001997312,0.0001093856,0.0002123469,0.0002783529,0.0001839161,0.00009567375,0.0002194804,0.0002429017,0.0001317422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001195393,"about_ca_system_score_gemma":0.0001083308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007893746,"about_ca_topic_score_gemma":0.001237998,"domain_scores_codex":[0.9999405,0.000006822984,0.000005627301,0.00002051191,0.00001265268,0.00001393928],"domain_scores_gemma":[0.9999143,0.000008026658,0.00003631956,0.00000654496,0.0000201662,0.00001461878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001439544,0.00007542739,0.1072718,0.0001541286,0.0002222186,0.001016399,0.0004304423,0.0000855843,0.8790187,0.0000753159,0.0001949953,0.01001533],"study_design_scores_gemma":[0.00001473711,0.0004236613,0.9498447,0.00001877741,0.0001247727,0.002593438,0.0005044469,0.0005219283,0.04503395,0.000178102,0.0007269263,0.00001449481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981589,0.0007630039,0.000499401,0.00002999749,0.000006534766,0.000005863634,0.0003220479,0.00001111573,0.0002031178],"genre_scores_gemma":[0.997573,0.0006388525,0.0007738805,0.0000520217,0.000006813539,0.00001353436,0.0005446202,0.000005928937,0.0003914461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007893746,"threshold_uncertainty_score":0.002107024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008560685003601498,"score_gpt":0.2557911433919438,"score_spread":0.2472304583883423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}