{"id":"W4406387153","doi":"10.1172/jci187567","title":"A new twist on superantigen-activated autoimmune disease","year":2025,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Superantigen; Autoimmune disease; Immunology; Medicine; Twist; Computational biology; Biology; Immune system; T cell; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002896058,0.0007545437,0.001140068,0.0006557342,0.001478896,0.003296647,0.001183774,0.01503011,0.003368583],"category_scores_gemma":[0.006214292,0.0003998747,0.00066993,0.000358415,0.003776637,0.004830088,0.001379739,0.02972704,0.001968978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001688909,"about_ca_system_score_gemma":0.001231272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003687162,"about_ca_topic_score_gemma":0.0009454699,"domain_scores_codex":[0.9982368,0.0004788037,0.0002498591,0.0002498291,0.0005714555,0.000213226],"domain_scores_gemma":[0.9947404,0.003076357,0.0002445543,0.0003378865,0.0008579712,0.0007429234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002274071,0.0001291999,0.0008046804,0.0004027227,0.00004327564,0.006829319,0.0002742925,0.00008801547,0.002379746,0.01850064,0.9184794,0.05184127],"study_design_scores_gemma":[0.0001372996,0.0001417183,0.0006137373,0.0002467308,0.0000274247,0.006100531,0.0002638765,0.0003058086,0.0006077034,0.02217371,0.9693443,0.00003703661],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001338619,0.02278859,0.0005826485,0.869538,0.101831,0.00001214552,0.00003918141,0.00009604514,0.003773779],"genre_scores_gemma":[0.01391134,0.02607899,0.0007666608,0.5366482,0.4161893,0.00002812332,0.00003760777,0.00003875836,0.006301014],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01503011,"threshold_uncertainty_score":0.01531601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143174601528613,"score_gpt":0.3281871590537729,"score_spread":0.2967554130384868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}