{"id":"W4406400396","doi":"10.54254/2753-8818/2025.gu20456","title":"CRISPR/Cas9-Enhanced CAR-T Cell Therapy for Hematological Malignancies","year":2025,"lang":"en","type":"article","venue":"Theoretical and Natural Science","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"CRISPR; CAR T-cell therapy; Medicine; Cancer research; Biology; Internal medicine; Cancer; Immunotherapy; Chimeric antigen receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117991,0.0002906459,0.0002994201,0.0003526865,0.0001947693,0.0003815131,0.000310227,0.0004401118,0.002231715],"category_scores_gemma":[0.0001865585,0.0001055569,0.0003166343,0.0001984219,0.0002967935,0.0002631741,0.0003219039,0.0007515362,0.0004097326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004026902,"about_ca_system_score_gemma":0.0005746763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008634248,"about_ca_topic_score_gemma":0.001236085,"domain_scores_codex":[0.9998114,0.00003900208,0.00001602384,0.00004011799,0.00006334649,0.00003028785],"domain_scores_gemma":[0.9999503,0.00001158743,0.00001195113,0.000007772123,0.000009623274,0.000008790532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003435937,0.0001975533,0.0008963087,0.0007080588,0.00007112535,0.0005506306,0.00008167808,0.002640827,0.8764862,0.006003166,0.004063325,0.1079575],"study_design_scores_gemma":[0.0001868367,0.001096814,0.002373796,0.00008515315,0.0001496621,0.003204974,0.00006978217,0.01231472,0.8898802,0.002079342,0.08852153,0.00003720889],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6183508,0.05954405,0.2673773,0.003175677,0.0009550073,0.000792136,0.001431734,0.003410886,0.0449624],"genre_scores_gemma":[0.9563884,0.0104938,0.0247917,0.0005598135,0.00005705759,0.0001910397,0.000491326,0.00006559771,0.006961211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002231715,"threshold_uncertainty_score":0.007465839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313126416633361,"score_gpt":0.3319525780267485,"score_spread":0.3188213138604149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}