{"id":"W4406400543","doi":"10.2174/0115734064310145240822060730","title":"An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive","year":2025,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Nilotinib; Dasatinib; Kinase; Docking (animal); Kinome; Pharmacology; Parkinson's disease; Chemistry; In silico; Tyrosine kinase; Biochemistry; Biology; Medicine; Signal transduction; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005454432,0.001487537,0.00150928,0.001321372,0.0005795943,0.001152329,0.001364126,0.001359923,0.004795654],"category_scores_gemma":[0.001193349,0.0005891212,0.001783163,0.0009172541,0.0002834677,0.000484347,0.0007430019,0.0008775995,0.0005667536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007430905,"about_ca_system_score_gemma":0.001996728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009862406,"about_ca_topic_score_gemma":0.01418078,"domain_scores_codex":[0.9998507,0.00004444907,0.00001020794,0.00002574444,0.0000379596,0.00003083764],"domain_scores_gemma":[0.9996845,0.0001959685,0.00002490764,0.00001366228,0.00005165641,0.00002938508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002910176,0.000279346,0.002764917,0.0004236218,0.0003811044,0.0003147965,0.00005264105,0.968631,0.002255949,0.004107957,0.002597085,0.01790066],"study_design_scores_gemma":[0.00005048976,0.00006251622,0.0002113894,0.00001376576,0.00007174276,0.00002746864,0.00002462172,0.9966912,0.0003419863,0.001282191,0.001217036,0.000005485106],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5673674,0.007739284,0.3600677,0.002537207,0.0004392802,0.0008952381,0.01020843,0.007017445,0.04372811],"genre_scores_gemma":[0.7640687,0.002091937,0.2184618,0.0005756511,0.00008895835,0.001135149,0.008130327,0.000381512,0.005065901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009862406,"threshold_uncertainty_score":0.01960999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263559118799483,"score_gpt":0.2803892550663238,"score_spread":0.2677536638783289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}