{"id":"W4406401546","doi":"10.1101/2025.01.14.632594","title":"Extensive length and homology dependent chimerism in pool-packaged AAV libraries","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Electrowetting and Microfluidic Technologies","field":"Engineering","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Cancer Research Society; Damon Runyon Cancer Research Foundation","keywords":"Homology (biology); Computational biology; Biology; Genetics; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005574721,0.000356613,0.0003480301,0.0002398094,0.0001913829,0.000654705,0.0002614048,0.0003858307,0.00137184],"category_scores_gemma":[0.0008928695,0.0002415893,0.000265228,0.0002180131,0.0005806003,0.0005274276,0.0009929631,0.000925492,0.0004877748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002690974,"about_ca_system_score_gemma":0.0003087946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002185375,"about_ca_topic_score_gemma":0.0002951487,"domain_scores_codex":[0.9990884,0.000157861,0.00005676175,0.0002879374,0.0002936223,0.0001154311],"domain_scores_gemma":[0.9992902,0.0001925928,0.000207415,0.0001698704,0.00005560226,0.00008426847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003105184,0.0000142138,0.0001882501,0.00002188889,0.000007946197,0.00006680793,0.00003466423,0.0002009694,0.9970745,0.0002925337,0.00005041523,0.002016683],"study_design_scores_gemma":[0.000002971545,0.00008084212,0.0009337352,0.000003590946,0.000007863652,0.0003038316,0.00001300155,0.0007780333,0.9965958,0.0001128565,0.001163124,0.000004433251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9069953,0.0009981948,0.08590063,0.0001633828,0.0000404594,0.0001116474,0.000389904,0.0008210198,0.004579471],"genre_scores_gemma":[0.9804293,0.0003058722,0.01442361,0.0001403959,0.000006983465,0.00007735637,0.0003913424,0.0002287822,0.003996192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00137184,"threshold_uncertainty_score":0.00458926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006267468732179425,"score_gpt":0.188122227053143,"score_spread":0.1818547583209635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}