{"id":"W4406407977","doi":"10.1111/cpr.13788","title":"Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting <scp> <i>MLH1</i> </scp> and <scp> <i>TP53</i> </scp> Deficient Tumours","year":2025,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation","keywords":"Ploidy; Biology; Genome; Lethality; Synthetic lethality; Microbiology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141283,0.0004482641,0.0003097083,0.0003993257,0.0001109409,0.0002701939,0.0001823937,0.0003777445,0.001723248],"category_scores_gemma":[0.0001190039,0.0001487902,0.0003193549,0.000268499,0.0002709022,0.00008955073,0.000171445,0.0006321167,0.0004742178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933595,"about_ca_system_score_gemma":0.000129982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005626641,"about_ca_topic_score_gemma":0.0007670745,"domain_scores_codex":[0.9997861,0.00002713684,0.00002345136,0.00005961073,0.00007506947,0.00002866968],"domain_scores_gemma":[0.9998017,0.00007374662,0.00004979221,0.00002219436,0.00001350004,0.00003909786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002860311,0.00001036619,0.0001099477,0.00001260755,0.00000436408,0.00003847097,0.000006863102,0.00007587548,0.9991354,0.00003426375,0.00002638205,0.0005168445],"study_design_scores_gemma":[0.000008170855,0.0002100393,0.003531609,0.000002449576,0.00001617353,0.0001980063,0.00001840744,0.0009490148,0.9940064,0.00002265342,0.001033599,0.000003571867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839378,0.001043244,0.00985115,0.0001443182,0.00003312226,0.00008267249,0.002681646,0.0003867006,0.001839375],"genre_scores_gemma":[0.9839696,0.0007975022,0.006181818,0.0001141809,0.000006719511,0.00008736278,0.004269825,0.00009564428,0.004477406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723248,"threshold_uncertainty_score":0.005764902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640906903418326,"score_gpt":0.2552971902097024,"score_spread":0.2388881211755191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}