{"id":"W4406408418","doi":"10.1101/2025.01.14.25320259","title":"Glymphatic defect in isolated REM sleep behavior disorder is associated with phenoconversion to Parkinson’s disease","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital; Montreal Neurological Institute and Hospital; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal; Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Janssen Pharmaceuticals; Canadian Institutes of Health Research; Sanofi Genzyme; Allergan; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Parkinson Canada; Agence Nationale de la Recherche; Avid Radiopharmaceuticals; Ministerstvo Školství, Mládeže a Tělovýchovy; Voyager Therapeutics; Parkinson's UK; Fondation Brain Canada; AbbVie; European Commission; Denali Therapeutics; Neurocrine Biosciences; Pfizer; Biogen; Celgene; National Institute for Health and Care Research; Meso Scale Diagnostics; Verily Life Sciences; Teva Pharmaceutical Industries; Agentura Pro Zdravotnický Výzkum České Republiky; Sanofi; GlaxoSmithKline; Alzheimer Society; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Parkinson's disease; REM sleep behavior disorder; Glymphatic system; Sleep (system call); Medicine; Disease; Psychology; Neuroscience; Psychiatry; Internal medicine; Cerebrospinal fluid; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003915224,0.0004521814,0.0003655919,0.001043298,0.0004092861,0.0004445304,0.0003272612,0.0003930437,0.00236584],"category_scores_gemma":[0.001684774,0.0002463848,0.0004072766,0.0006740825,0.0003669023,0.0002301154,0.0005400177,0.0004089335,0.0002827605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641515,"about_ca_system_score_gemma":0.0001341812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002116778,"about_ca_topic_score_gemma":0.001914576,"domain_scores_codex":[0.9997198,0.00005395604,0.00003796353,0.0001134396,0.0000386038,0.00003616982],"domain_scores_gemma":[0.9986194,0.0002604508,0.0006417462,0.0001362082,0.0001135387,0.0002286178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004577191,0.00003392703,0.9960694,0.000007260652,0.0000563689,0.0006475821,0.00006954838,0.00004330804,0.001710353,0.00001935,0.0000430002,0.0008420749],"study_design_scores_gemma":[0.000004679481,0.00008615822,0.9984452,0.000003116083,0.00001802071,0.001020944,0.00005457061,0.0001776841,0.0001200846,0.00002186449,0.00004529468,0.000002388505],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995744,0.00007414637,0.0000931606,0.000008768166,0.00000270856,0.000004056445,0.00009383845,0.000003373498,0.0001456583],"genre_scores_gemma":[0.9996901,0.00002562621,0.00006573606,0.000005731313,0.000004077884,0.000002418275,0.0001397963,0.00000229348,0.00006424893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00236584,"threshold_uncertainty_score":0.007914484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01829118120678561,"score_gpt":0.2637463753829828,"score_spread":0.2454551941761972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}