{"id":"W4406421266","doi":"10.1101/2025.01.14.633055","title":"An MRI-informed histo-molecular analysis implicates ependymal cells in the pathogenesis of periventricular pathology in multiple sclerosis","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Pathology; Multiple sclerosis; Pathogenesis; Medicine; Neuroscience; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444056,0.0002223536,0.0001665586,0.0005692418,0.0002083047,0.0002948655,0.0001473594,0.000232001,0.0009723081],"category_scores_gemma":[0.0001548875,0.0001153332,0.0001307107,0.0001979157,0.0002494569,0.0001554164,0.0002116937,0.0002960697,0.0002893862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001216672,"about_ca_system_score_gemma":0.0001069619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00039462,"about_ca_topic_score_gemma":0.0006287106,"domain_scores_codex":[0.9999431,0.000006999429,0.000006360957,0.00001869917,0.00001310568,0.00001178467],"domain_scores_gemma":[0.9999012,0.00001849656,0.00002513567,0.00001313332,0.00002243094,0.00001961148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009875622,0.00001100632,0.003668376,0.00003406924,0.000009317539,0.0003234743,0.00003624197,0.00005379615,0.9939278,0.000118137,0.00001480049,0.001704265],"study_design_scores_gemma":[0.00001445564,0.0004495017,0.2132603,0.00002567474,0.0001043232,0.003692061,0.0003917022,0.003150476,0.7742751,0.001181404,0.003442634,0.00001230675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924298,0.0006456357,0.005674317,0.00002940843,0.00001119722,0.00002040134,0.0002746517,0.00003945369,0.0008751352],"genre_scores_gemma":[0.9937009,0.0003951104,0.004497875,0.00003248491,0.000008067014,0.00001739231,0.0003128651,0.00001093239,0.001024473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009723081,"threshold_uncertainty_score":0.003252685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220348018053136,"score_gpt":0.2280978566995049,"score_spread":0.2158943765189736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}