{"id":"W4406423489","doi":"10.1007/s00401-025-02847-w","title":"White matter pathology in FTLD caused by GRN mutations","year":2025,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"National Institutes of Health; Alzheimer's Association","keywords":"Pathology; White matter; Medicine; Frontotemporal lobar degeneration; Biology; Disease; Magnetic resonance imaging; Dementia; Radiology; Frontotemporal dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001210126,0.001391316,0.001395081,0.001644545,0.001614447,0.001253648,0.001320554,0.01307326,0.002821322],"category_scores_gemma":[0.00538943,0.0005952757,0.000830174,0.0008711797,0.002229833,0.001231218,0.0006866617,0.003819622,0.001147421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001480697,"about_ca_system_score_gemma":0.000608851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002493116,"about_ca_topic_score_gemma":0.002661431,"domain_scores_codex":[0.9993962,0.0001379482,0.00009078904,0.0001076297,0.0001262404,0.0001411316],"domain_scores_gemma":[0.9976543,0.001454689,0.0001928897,0.0001662612,0.0001958535,0.0003360851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007592825,0.00008708937,0.00602341,0.0001366456,0.00003822222,0.9575421,0.0001338294,0.0002273729,0.002760511,0.001212123,0.02512533,0.005954028],"study_design_scores_gemma":[0.000524082,0.0004833501,0.03390584,0.0002804147,0.0002257179,0.928005,0.0002521742,0.004489653,0.002958101,0.0108755,0.01790239,0.00009785041],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.4992469,0.0136895,0.004498167,0.3608923,0.02347254,0.0002449333,0.0005874091,0.0007471158,0.09662104],"genre_scores_gemma":[0.8922626,0.002938931,0.001472732,0.05145587,0.04289201,0.00006920384,0.0001173078,0.0000916011,0.008699702],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.01307326,"threshold_uncertainty_score":0.01074326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008897898163763438,"score_gpt":0.2358811302440016,"score_spread":0.2269832320802382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}