{"id":"W4406427304","doi":"10.1101/2025.01.13.632753","title":"From macro to micro: De novo genomes of Aedes mosquitoes enable comparative genomics among close and distant relatives","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Insect symbiosis and bacterial influences","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"Biology; Genome; Synteny; Comparative genomics; Aedes aegypti; Evolutionary biology; Genetics; Reference genome; Genomics; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002784902,0.0003636544,0.0003181226,0.0004241127,0.0002956207,0.0006569364,0.0002826028,0.0002596878,0.001835435],"category_scores_gemma":[0.0007123869,0.0002389943,0.0003381641,0.0006331822,0.0001223264,0.0004206241,0.0004800787,0.0006613201,0.0007693714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089442,"about_ca_system_score_gemma":0.000285784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384185,"about_ca_topic_score_gemma":0.00347892,"domain_scores_codex":[0.9998906,0.00001373084,0.000007335204,0.00005370813,0.00002053316,0.00001414424],"domain_scores_gemma":[0.9996486,0.0001329847,0.0000628316,0.00005754518,0.0000597619,0.00003834353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003613038,0.00004902276,0.005953871,0.0003669421,0.0000741564,0.0003337055,0.0002931234,0.002490629,0.9610245,0.001692576,0.001256189,0.026104],"study_design_scores_gemma":[0.0001636141,0.0006935789,0.1672727,0.0002857418,0.0003750954,0.001902599,0.0008381167,0.03546359,0.5425631,0.005842707,0.2444877,0.0001114929],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8562104,0.002586427,0.09056393,0.000453799,0.0001508433,0.0001517334,0.04318762,0.001553711,0.005141618],"genre_scores_gemma":[0.7643563,0.001748677,0.1483141,0.0002114976,0.00005525712,0.0001576896,0.08133633,0.0008199363,0.003000235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835435,"threshold_uncertainty_score":0.006140172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689660829683464,"score_gpt":0.2230681906524114,"score_spread":0.2061715823555767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}