{"id":"W4406429462","doi":"10.1002/dad2.70072","title":"sTREM2 in discordant CSF Aβ<sub>42</sub> and p‐tau181","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002796957,0.0004132934,0.0005006897,0.0003574264,0.000176212,0.000163107,0.0001793013,0.00006676419,0.00006734137],"category_scores_gemma":[0.00005462124,0.0004148078,0.0002529277,0.0004808698,0.00009910443,0.0002241229,0.0002794013,0.000270195,0.00001148646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007018591,"about_ca_system_score_gemma":0.0002806718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002187228,"about_ca_topic_score_gemma":0.00006763772,"domain_scores_codex":[0.997356,0.0001067518,0.0005676334,0.000793104,0.0005653688,0.0006111556],"domain_scores_gemma":[0.9986264,0.0001346917,0.000100235,0.0006317735,0.00008317934,0.000423734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006218698,0.0009563065,0.9009553,0.000106319,0.003267427,0.00008249853,0.00005277133,0.00005056348,0.001118959,0.0001530224,0.0006442623,0.09255037],"study_design_scores_gemma":[0.002582408,0.000082601,0.9683221,0.0007043527,0.008474192,0.000001423432,0.0004613076,0.0002134882,0.01702966,0.0002890472,0.00147351,0.0003658951],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9234253,0.07223445,0.000230137,0.001417759,0.0007816447,0.001028438,0.00001622756,0.00008006207,0.0007859842],"genre_scores_gemma":[0.9908862,0.007068225,0.0006511682,0.0002610399,0.0001593017,0.0008547948,0.00006188767,0.00004665047,0.00001069329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09218448,"threshold_uncertainty_score":0.9998304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555518622851246,"score_gpt":0.3112639036498759,"score_spread":0.2957087174213635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}