{"id":"W4406430875","doi":"10.3390/cancers17020281","title":"MET Activation in Lung Cancer and Response to Targeted Therapies","year":2025,"lang":"en","type":"review","venue":"Cancers","topic":"Liver physiology and pathology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Cancer Institute; BC Cancer Foundation; Terry Fox Research Institute","keywords":"Carcinogenesis; Receptor tyrosine kinase; Cancer research; Signal transduction; Biology; Tyrosine kinase; Hepatocyte Growth Factor Receptor; Cancer; Bioinformatics; Hepatocyte growth factor; Medicine; Receptor; Cell biology; Genetics; C-Met","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670238,0.0001585014,0.0008076757,0.0002664774,0.0000258188,0.000002722732,0.00005345517,0.000223128,0.00007177785],"category_scores_gemma":[0.0001119677,0.0001231833,0.00006364178,0.0003220572,0.00004780473,0.00002300645,0.0000281189,0.0002494316,0.000002477354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009558811,"about_ca_system_score_gemma":0.002031214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001868867,"about_ca_topic_score_gemma":0.00003458459,"domain_scores_codex":[0.9991679,0.0002178559,0.0001678124,0.0002627862,0.00004214607,0.0001415125],"domain_scores_gemma":[0.9994174,0.0002903737,0.00006414772,0.0001571494,0.00002612038,0.0000448657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001418576,0.000007699127,0.0002145029,0.01614866,0.0003700895,0.00002389336,0.001499177,0.000008166534,0.0003509412,0.00005114325,0.004022058,0.9758851],"study_design_scores_gemma":[0.0005008744,0.0001301092,0.001740516,0.01890785,0.0004392425,0.00000408691,0.00005995715,0.000002316971,0.00002817307,0.00002124303,0.9779919,0.0001737158],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005757002,0.9928311,0.000005602229,0.0002112261,0.0002606187,0.0007116275,0.0000316697,0.00001624941,0.000174921],"genre_scores_gemma":[0.0005032053,0.9967938,0.000065229,0.0008216775,0.00008569546,0.0003963614,0.00003927548,0.00001227959,0.001282454],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9757114,"threshold_uncertainty_score":0.502327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410187347433004,"score_gpt":0.384813122279608,"score_spread":0.3507112488052779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}