{"id":"W4406433902","doi":"10.1016/j.vaccine.2025.126709","title":"Adjuvant-dependent impacts on vaccine-induced humoral responses and protection in preclinical models of nasal and genital colonization by pathogenic Neisseria","year":2025,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada); Muscular Dystrophy Canada; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Canada Research Chairs","keywords":"Adjuvant; Immunology; Neisseria meningitidis; Neisseria; Colonization; Biology; Microbiology; Humoral immunity; Meningococcal vaccine; Neisseria gonorrhoeae; Medicine; Virology; Immune system; Immunization; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004953279,0.0005900467,0.0003891781,0.0003419938,0.000148257,0.0004066886,0.0002830823,0.0005759255,0.001811864],"category_scores_gemma":[0.0005868429,0.0001956353,0.0003194602,0.000140939,0.0004128733,0.0004684593,0.0002164431,0.001969925,0.0003485159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002682661,"about_ca_system_score_gemma":0.0005369392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005252456,"about_ca_topic_score_gemma":0.001302486,"domain_scores_codex":[0.9995884,0.00007535817,0.00002802838,0.00005346835,0.00007283118,0.0001819074],"domain_scores_gemma":[0.9996148,0.00008893487,0.00008581313,0.0000426571,0.00006677597,0.0001010451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006830735,0.002547288,0.0005520412,0.0001342196,0.00001540226,0.00006440359,0.00005221435,0.0003567958,0.9825848,0.0001628295,0.0001198043,0.00657939],"study_design_scores_gemma":[0.0006816922,0.05015501,0.01379735,0.00006884722,0.0001476573,0.000250792,0.0001399261,0.001775151,0.9297759,0.000307712,0.002878426,0.00002166479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970754,0.0007853142,0.000457394,0.00007522135,0.00007807392,0.00007946754,0.000292822,0.00003146474,0.001124791],"genre_scores_gemma":[0.9950488,0.0007240942,0.000787805,0.0001133004,0.00003667763,0.00007970925,0.0005775893,0.00002041508,0.002611461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811864,"threshold_uncertainty_score":0.006061256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02802188022419951,"score_gpt":0.299442366600204,"score_spread":0.2714204863760045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}