{"id":"W4406433963","doi":"10.1093/braincomms/fcae432","title":"Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; NHS Innovation Accelerator; National Institute of Neurological Disorders and Stroke; University of California, San Francisco; AlzOut","keywords":"Frontotemporal dementia; Cerebrospinal fluid; Dementia; Cohort; Oncology; Medicine; Internal medicine; Psychology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009905426,0.0001242656,0.0001191771,0.0002209261,0.0001426161,0.00005411496,0.000133882,0.0000219029,0.00001758173],"category_scores_gemma":[0.0001565336,0.00009837917,0.00003375995,0.0003717904,0.0001715508,0.0001256718,0.00009474219,0.0001982319,0.00001206935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007334889,"about_ca_system_score_gemma":0.0003114549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001368909,"about_ca_topic_score_gemma":0.0002919804,"domain_scores_codex":[0.9990661,0.0001616198,0.0001489077,0.0002542853,0.00019359,0.000175473],"domain_scores_gemma":[0.998445,0.0004123366,0.00002416631,0.0007352566,0.00005018786,0.0003330733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007234648,0.001330396,0.955268,0.0006102127,0.001894972,0.001068608,0.006333287,0.0001057304,0.0001289023,0.008449598,0.004191,0.01989578],"study_design_scores_gemma":[0.001180315,0.0001269806,0.9801871,0.0008749053,0.0001443679,0.00001227614,0.0002944985,0.01441093,0.00002407985,0.0005890065,0.002015098,0.000140455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9164736,0.02982307,0.00007776589,0.05231289,0.00001605293,0.0007257473,0.00007248123,0.00008979408,0.0004085534],"genre_scores_gemma":[0.9973273,0.0009416565,0.0006166007,0.0003982841,0.00001870808,0.0001170483,0.0004270159,0.0000262114,0.0001271662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08085367,"threshold_uncertainty_score":0.4011786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336664590689428,"score_gpt":0.329997388578893,"score_spread":0.2966307426719987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}