{"id":"W4406435712","doi":"10.3390/ijms26020735","title":"Structure-Function Relationship of the β-Hairpin of Thermus thermophilus HB27 Laccase","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Enzyme-mediated dye degradation","field":"Agricultural and Biological Sciences","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Universidad Nacional Autónoma de México; Canadian Light Source","keywords":"Thermus thermophilus; Active site; Mutant; Chemistry; Laccase; Copper; Enzyme; Thermus; Redox; Wild type; Biochemistry; Stereochemistry; Crystallography; Escherichia coli; Gene; Thermophile; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003435,0.0003086063,0.0001979236,0.000200063,0.00009648118,0.0002417596,0.0002031419,0.0002422991,0.0009450606],"category_scores_gemma":[0.000169268,0.00007936666,0.0003134219,0.000201077,0.000116868,0.0001381429,0.0001064022,0.0002527358,0.0002646039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002720718,"about_ca_system_score_gemma":0.0001091131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007915685,"about_ca_topic_score_gemma":0.0003645423,"domain_scores_codex":[0.9999378,0.00001137653,0.000004160368,0.00001306178,0.00001997527,0.00001357425],"domain_scores_gemma":[0.9998847,0.00002277744,0.00002614301,0.00000553516,0.00002793769,0.00003294842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001686497,0.00003392683,0.001334799,0.00003078368,0.00001370176,0.0001327198,0.00003937977,0.0003882439,0.9962822,0.00009862237,0.00003823787,0.001438928],"study_design_scores_gemma":[0.00002067881,0.0003341304,0.02666991,0.00000875733,0.0000318544,0.0005891192,0.00007490888,0.007925141,0.9624053,0.0001455253,0.00177522,0.00001939927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981872,0.0004537056,0.0008448179,0.00002018545,0.000003248726,0.000006843289,0.0001855869,0.0000246711,0.0002737677],"genre_scores_gemma":[0.9982697,0.0001445954,0.0006354068,0.00001027305,0.00000253256,0.000004768399,0.0004972538,0.000008157243,0.0004273919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009450606,"threshold_uncertainty_score":0.00316155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329800978782761,"score_gpt":0.2460325372527186,"score_spread":0.232734527464891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}