{"id":"W4406439461","doi":"10.1097/qad.0000000000004116","title":"Brain RNA profiling highlights multiple disease pathways in persons with HIV-associated neurocognitive disorder","year":2025,"lang":"en","type":"article","venue":"AIDS","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Mental Health","keywords":"Profiling (computer programming); Computational biology; RNA; Disease; Biology; Bioinformatics; Medicine; Neuroscience; Genetics; Pathology; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001455723,0.0002490696,0.0002153032,0.0006155364,0.0002870133,0.0003655114,0.0001047392,0.0002295837,0.001160734],"category_scores_gemma":[0.0005155636,0.00008833434,0.0001634301,0.0003724594,0.0001967805,0.0001494922,0.0002249112,0.000185254,0.0001533061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892623,"about_ca_system_score_gemma":0.0001291384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277992,"about_ca_topic_score_gemma":0.002199845,"domain_scores_codex":[0.9998904,0.00001740896,0.000009932502,0.00003931698,0.00002184585,0.00002109447],"domain_scores_gemma":[0.9998331,0.0000525519,0.00007003068,0.000007295395,0.00002062147,0.00001628019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001172527,0.0000917286,0.8581752,0.00009011936,0.0001166602,0.002020355,0.0004042891,0.000388112,0.1119457,0.0001171928,0.00029478,0.02518331],"study_design_scores_gemma":[0.00000651585,0.0001936449,0.9872569,0.00001899023,0.00004921043,0.002651931,0.0003606771,0.0007814839,0.008157018,0.000166546,0.0003514408,0.00000567991],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985787,0.0003329735,0.0003779851,0.00003385086,0.000001636233,0.000006624146,0.000230837,0.00001087125,0.0004266877],"genre_scores_gemma":[0.9986392,0.0001926148,0.0006575215,0.00005037925,0.00000616258,0.000009651796,0.0002481741,0.000003372573,0.0001928122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277992,"threshold_uncertainty_score":0.003883064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048576364436855,"score_gpt":0.2409308919079999,"score_spread":0.2304451282636313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}