{"id":"W4406439461","doi":"10.1097/qad.0000000000004116","title":"Brain RNA profiling highlights multiple disease pathways in persons with HIV-associated neurocognitive disorder","year":2025,"lang":"en","type":"article","venue":"AIDS","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Mental Health","keywords":"Profiling (computer programming); Computational biology; RNA; Disease; Biology; Bioinformatics; Medicine; Neuroscience; Genetics; Pathology; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009749725,0.0001544964,0.0001887972,0.0001698312,0.0001797335,0.00001439803,0.000110547,0.00008524943,0.00008581695],"category_scores_gemma":[0.0003184004,0.0001137401,0.00005443839,0.0003108096,0.0001251114,0.0000640803,0.00005976488,0.0002374604,0.0003204449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006672308,"about_ca_system_score_gemma":0.0001830141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001988965,"about_ca_topic_score_gemma":0.0003600974,"domain_scores_codex":[0.9988357,0.0002584605,0.0001319835,0.0003134678,0.00003920711,0.0004211737],"domain_scores_gemma":[0.999343,0.0003725865,0.00003131356,0.0001580805,0.00005163276,0.00004335345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001198001,0.001550967,0.954093,0.00003632314,0.0005560484,0.0003159092,0.000925403,0.00001175898,0.03067382,0.001834746,0.002504779,0.006299253],"study_design_scores_gemma":[0.02043458,0.001251397,0.9247054,0.000352258,0.000161821,0.0000050415,0.001731661,0.00009816697,0.03580698,0.0004253272,0.01449803,0.000529262],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942891,0.0008372287,0.0001421195,0.00155821,0.00007150129,0.0005660377,0.0004181365,0.00007417431,0.002043509],"genre_scores_gemma":[0.9930023,0.00002253972,0.00004059863,0.0002124061,0.000004781029,0.0001970621,0.0007697082,0.0000119531,0.005738629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02938752,"threshold_uncertainty_score":0.4638188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048576364436855,"score_gpt":0.2409308919079999,"score_spread":0.2304451282636313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}