{"id":"W4406440193","doi":"10.1126/science.adi4736","title":"Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis","year":2025,"lang":"en","type":"article","venue":"Science","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; College of Engineering, Michigan State University; Institut de Recherche Clinique De Montréal; Novo Nordisk; Cedars-Sinai Medical Center; McGill University; Natural Sciences and Engineering Research Council of Canada; Irving Medical Center, Columbia University; University of California, San Diego; Regeneron Pharmaceuticals; University of Cincinnati; AstraZeneca; Eli Lilly and Company; Canadian Institutes of Health Research; University of Washington; Michigan State University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Myostatin; Endocrine system; Hormone; Endocrinology; Internal medicine; Follicle-stimulating hormone; Follicle; Endocrine gland; Biology; Skeletal muscle; Medicine; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112645,0.0002028215,0.0001150301,0.0001577595,0.0001393035,0.0002718743,0.00009993975,0.0001443079,0.001175192],"category_scores_gemma":[0.00008578867,0.0001152645,0.0001213245,0.00008973991,0.0002098483,0.0001570711,0.000246728,0.0002829795,0.0004062649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201892,"about_ca_system_score_gemma":0.0001944926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006009965,"about_ca_topic_score_gemma":0.001419678,"domain_scores_codex":[0.9999319,0.000007418424,0.000003576019,0.00002042242,0.00002225688,0.00001431945],"domain_scores_gemma":[0.9999349,0.000007514315,0.00001899102,0.000005462137,0.000008309359,0.00002479676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003214694,0.000002136496,0.0007679374,0.00001226248,0.000002128865,0.00004840083,0.000009162359,0.00002470856,0.9975975,0.0002430125,0.0000366189,0.001223987],"study_design_scores_gemma":[0.00001777277,0.0002214346,0.08747191,0.0000309658,0.00002389465,0.001063405,0.0001303152,0.001140923,0.8922052,0.0004973128,0.01718715,0.000009689039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797595,0.004062104,0.007844764,0.0003756417,0.00006529592,0.00001536975,0.000376224,0.0001329879,0.007368058],"genre_scores_gemma":[0.9921365,0.00128648,0.00230237,0.00009296786,0.00002082427,0.000008781424,0.0002525413,0.00002581358,0.003873731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175192,"threshold_uncertainty_score":0.003931403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00690892687471171,"score_gpt":0.266744753435553,"score_spread":0.2598358265608413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}