{"id":"W4406463200","doi":"10.1007/s11060-024-04930-w","title":"It’s all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma","year":2025,"lang":"en","type":"review","venue":"Journal of Neuro-Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Glioblastoma; MAPK/ERK pathway; Downstream (manufacturing); Resistance (ecology); Cancer research; Cell biology; Biology; Signal transduction; Business; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472319,0.0004654948,0.0005468758,0.001055509,0.0002255561,0.0007918152,0.0003991509,0.0007670025,0.002986596],"category_scores_gemma":[0.0003856597,0.0001096819,0.0004222455,0.0009241192,0.0002455202,0.00110147,0.0003458731,0.001190375,0.001482034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004288651,"about_ca_system_score_gemma":0.0009540124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008886792,"about_ca_topic_score_gemma":0.001587618,"domain_scores_codex":[0.9999281,0.00001234668,0.000009621619,0.00001373134,0.00002501845,0.00001106393],"domain_scores_gemma":[0.9998887,0.00003375507,0.00001556935,0.000003728029,0.00004537968,0.00001276359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001072378,0.00004646875,0.0002656259,0.01368391,0.00008319164,0.0002816931,0.0000958747,0.0002930475,0.003940892,0.004846456,0.0588722,0.9174834],"study_design_scores_gemma":[0.00001281953,0.0001005282,0.0009067504,0.003091414,0.00009071412,0.001649326,0.00008537992,0.00008221249,0.00116437,0.002655561,0.9901451,0.00001590807],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002956804,0.995935,0.0001891541,0.00117438,0.000696498,0.000005627882,0.00003208348,0.00001463788,0.001657025],"genre_scores_gemma":[0.001662793,0.9957733,0.0001891399,0.0005485968,0.000299618,0.000005468939,0.00004474061,0.000002662066,0.001473756],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002986596,"threshold_uncertainty_score":0.009991229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411078579574439,"score_gpt":0.3087133911173447,"score_spread":0.2846026053216004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}